A comparison of cyclophosphamide, adriamycin, 5‐fluorouracil (CAF) and cyclophosphamide, methotrexate, 5‐fluorouracil, vincristine, prednisone (CMFVP) in patients with metastatic breast cancer. A southeastern cancer study group project
A comparison of cyclophosphamide, adriamycin, 5‐fluorouracil (CAF) and cyclophosphamide, methotrexate, 5‐fluorouracil, vincristine, prednisone (CMFVP) in patients with metastatic breast cancer. A southeastern cancer study group project
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环磷酰胺、阿霉素、5-氟尿嘧啶 (CAF) 和环磷酰胺、甲氨蝶呤、5-氟尿嘧啶、长春新碱、泼尼松 (CMFVP) 在转移性乳腺癌患者中的比较 东南部癌症研究小组项目。
作者：
R. Smalley;J. Carpenter;A. Bartolucci;C. Vogel;S. Krauss
在一项正在进行的前瞻性随机研究中，113名可评估的患者接受了包括环磷酰胺、阿霉素和5-氟尿嘧啶(CAF)的三种药物组合或包括环磷酰胺、甲氨蝶呤、5-氟尿嘧啶、长春新碱和强的松的五种药物组合(CMFVP)，每4周间歇给药1周。CAF的有效率(%)、有效中位数(32周)和疾病控制中位数(32周)分别优于CMFVP(分别为37%、22周和17周)。继发于CAF的发病率显著，主要特征为恶心呕吐、身体不适、完全脱发和粒细胞减少。癌症40：625-632,1977。
In an ongoing prospective randomized study, 113 evaluable patients have received either a three‐drug combination that included cyclophosphamide, Adriamycin and 5‐fluorouracil (CAF) or a five‐drug combination including cyclophosphamide, methotrexate, 5‐fluorouracil, vincristine and prednisone (CMFVP) given intermittently 1 week out of 4. Responses (64%), median duration of response (32 weeks), and median duration of disease control (32 weeks) achieved with CAF were superior to those achieved with CMFVP (37%, 22 weeks, 17 weeks, respectively). Morbidity secondary to CAF was significant, with nausea and vomiting, malaise, total alopecia, and granulocytopenia being the main features. Cancer 40:625–632, 1977.