Dose-response relationships of accelerometer-measured sedentary behaviour and physical activity with non-alcoholic fatty liver disease
Dose-response relationships of accelerometer-measured sedentary behaviour and physical activity with non-alcoholic fatty liver disease
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DOI：
10.1111/apt.16631
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发表时间：
2021-10-11
影响因子：
7.6
通讯作者：
Arao, Takashi
中科院分区：
文献类型：
--
作者：
Tsunoda, Kenji;Kitano, Naruki;Arao, Takashi
背景：虽然一些研究已经证实了加速计测量的久坐行为(SB)和体力活动(PA)与非酒精性脂肪性肝病(NAFLD)的关联，但PA强度和相互依赖的日常运动行为的时间使用仍有待研究。目的利用三次样条法对加速度计测量的SB或PA与NAFLD之间的剂量-反应关系进行横断面检验，并通过成分数据分析来检验24小时内运动行为的相互依赖关系。方法数据来源于2017年5月至2020年2月在东京明治安田新宿医疗中心进行健康检查的1914名非重度饮酒者。用三轴加速度计测量SB、光强度PA(LPA)和中强度PA(MVPA)。超声诊断为脂肪肝。结果多变量调整后的Logistic模型显示MVPA与NAFLD呈负相关(优势比[OR]每600个代谢物[MET]-分钟/周=0.85，95%可信区间[CI]=0.76~0.96)。三次样条法分析显示，MVPA显示NAFLD的患病几率迅速下降至约1800 Met-min/周，然后温和下降。尽管在未调整体重指数(BMI)的模型中，SB与NAFLD显著相关，但在BMI调整的模型中，这一关联并不显著。在成分等时替代中，Sb重新分配给MVPA 60min/d使NAFLD的发生几率降低22%(OR=0.78，95%CI：0.65~0.93)，而MVPA重新分配60min/d使NAFLD发生几率增加69%(OR=1.69，95%CI：1.12~2.38)。结论MVPA和NAFLD之间的剂量-反应关系相反，证实了MVPA的增加是预防NAFLD的靶点。
Background Although a few studies have confirmed the association of accelerometer-measured sedentary behaviour (SB) and physical activity (PA) with non-alcoholic fatty liver disease (NAFLD), PA intensity and co-dependent daily time-use of movement behaviours are yet to be studied. Aims To cross-sectionally examine the dose-response relationship between accelerometer-measured SB or PA and NAFLD using cubic spline analysis and the interdependence of movement behaviours over 24 hours with compositional data analysis. Methods Data were obtained between May 2017 and February 2020 from 1914 people who were not heavy alcohol drinkers using health check-ups at the Meiji Yasuda Shinjuku Medical Center, Tokyo. SB, light-intensity PA (LPA) and moderate- to vigorous-intensity PA (MVPA) were evaluated using a triaxial accelerometer. Fatty liver was diagnosed by ultrasonography. Results A multivariable-adjusted logistic model showed an inverse association between MVPA and NAFLD (odds ratio [OR] per 600 metabolic equivalents [MET]-min/week = 0.85, 95% confidence interval [CI] = 0.76-0.96). MVPA showed rapidly decreasing odds of NAFLD to approximately 1800 MET-min/week in cubic spline analysis and then a moderate decline. Although SB was significantly associated with NAFLD in a body mass index (BMI)-unadjusted model, it was not significant in a BMI-adjusted model. In the compositional isotemporal substitution, reallocating 60 min/day of SB to MVPA decreased the odds of NAFLD by 22% (OR = 0.78, 95% CI: 0.65-0.93), whereas reallocating 60 min/day of MVPA to SB increased it by 69% (OR = 1.69, 95% CI: 1.12-2.38). Conclusions The inverse dose-response association between MVPA and NAFLD confirms increased MVPA as a target for the prevention of NAFLD.