PERSPECTIVE The Health Benefits Of Genomics: Out With The Old, In With The New
PERSPECTIVE The Health Benefits Of Genomics: Out With The Old, In With The New
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DOI：
10.1377/hlthaff.27.6.1612
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发表时间：
2008-11-01
期刊：
影响因子：
9.7
通讯作者：
Hudson, Kathy
中科院分区：
文献类型：
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作者：
Hudson, Kathy
对遗传学和基因组学发现研究的不成比例的重视需要通过资助转化研究的新方法，循证临床指南的制定和基因检测的强有力监管来平衡。这些措施将有助于确保患者，提供者和其他人能够更好地区分可以改善公共卫生的有效基因组应用和那些无用且可能有害的基因组应用。要做到这一点，我们就需要摒弃为人类基因组计划之前的世界设计的研究支持和监管指导模式，代之以像遗传学研究本身一样具有创新性的政策和计划。[Health Affairs 27，no. 6（2008）：1612-1615; 10.1377/hlthaff.27.6.1612]
The disproportionate emphasis on discovery research in genetics and genomics needs to be balanced by new approaches to funding translational research, development of evidence-based clinical guidelines, and robust regulation of genetic tests. These measures will help ensure that patients, providers, and others are better able to discriminate between valid genomic applications that can improve public health and those that are not useful and potentially harmful. Doing so will require that we dispense with models of research support and regulatory guidance designed for the pre-Human Genome Project world, and replace them with policies and programs as innovative as genetics research itself has been. [Health Affairs 27, no. 6 (2008): 1612-1615; 10.1377/hlthaff.27.6.1612]