Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines
Switching Photonic and Electrochemical Functions of a DNAzyme by DNA Machines
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DOI：
10.1021/nl303894h
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发表时间：
2013-01-01
期刊：
影响因子：
10.8
通讯作者：
Willner, Itamar
中科院分区：
文献类型：
--
作者：
Liu, Xiaoqing;Niazov-Elkan, Angelica;Willner, Itamar
描述了充当 DNA 机器的 DNA 纳米结构。具体来说，组装在核酸支架上并由燃料/反燃料链触发的DNA“行走者”在溶液中或表面（例如电极或半导体CdSe/ZnS量子点（QD））上被激活。 DNA机器导致DNA支架上血红素/G-四链体DNA酶的可切换形成或解离。这使得不同 DNA 机器的可切换状态的化学发光、化学发光共振能量转移 (CRET)、电化学或光电化学转导成为可能。
DNA nanostructures acting as DNA machines are described. Specifically, DNA "walkers" assembled on nucleic acid scaffolds and triggered by fuel/antifuel strands are activated in solution or on surfaces, for example, electrodes or semiconductor CdSe/ZnS quantum dots (QDs). The DNA machines led to the switchable formation or dissociation of the hemin/G-quadruplex DNAzyme on the DNA scaffolds. This enabled the chemiluminescence, chemiluminescence resonance energy transfer (CRET), electrochemical, or photoelectrochemical transduction of the switchable states of the different DNA machines.