Craniofacial growth in growth hormone-deficient rats.
Craniofacial growth in growth hormone-deficient rats.
复制标题
生长激素缺乏大鼠的颅面生长。
DOI：
10.1002/ar.a.20051
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Hinton,RobertJ
中科院分区：
文献类型：
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作者：
Vandeberg,JamesR;Buschang,PeterH;Hinton,RobertJ
虽然补充生长激素（GH）是一种公认的治疗GH缺乏或身材非常矮小的儿童的方法，但其对颅面骨骼的影响很少被研究。本研究的目的是使用混合纵向放射学设计，比较GH缺乏型侏儒大鼠与相同品系野生型大鼠颅面骨骼的绝对和相对生长。每周对4 - 9周龄的侏儒和野生型雌性刘易斯大鼠（每个时间间隔n = 14）的头部和后肢进行侧位和背腹侧位X线检查。扫描X线片，对27个头影测量点进行数字化，并测量点之间的选定线性距离。多水平统计程序被用来模拟头部不同区域的生长变化。在颅面测量中，两组的生长曲线在初始尺寸差异的大小和生长激素缺乏对生长速度的影响方面差异很大。在颅面测量中，相对成熟度也存在相当大的差异（65-97%）（即，在第一和最后时间间隔之间完成的生长百分比）。缺乏效应（生长激素对生长速度影响程度的定量估计）与特定测量的相对成熟度呈负相关（r =-0.52，P < 0.01）。生长激素效应对相对成熟度的依赖性表明，不同的颅面形态可能会导致取决于生长激素补充治疗的时机。Anat Rec Part A 278A：561-570，2004.© 2004 Wiley利斯公司
Although supplementation with growth hormone (GH) is an accepted treatment for children who are GH‐deficient or very small in stature, its effect on the craniofacial skeleton has been little studied. The goal of this study was to compare the absolute and relative growth of the craniofacial skeleton in GH‐deficient dwarf rats to that in wild‐type rats of the same strain, using a mixed‐longitudinal radiographic design. Lateral and dorsoventral X‐rays of the head and hindlimb were obtained weekly in dwarf and wild‐type female Lewis rats from 4 to 9 weeks of age (n = 14 for each time interval). The X‐rays were scanned, 27 cephalometric points were digitized, and selected linear distances were measured between points. Multilevel statistical procedures were used to model growth changes in different regions of the head. Among craniofacial measures, growth curves of the two groups differed greatly in the magnitude of initial size differences and the effect of GH deficiency on growth velocity. Considerable variation (65–97%) also existed among craniofacial measures with regard to relative maturity (i.e., the percentage of growth completed between the first and last time intervals). The deficiency effect (a quantitative estimate of the extent to which growth velocity was affected by GH) was negatively correlated (r = –0.52,P< 0.01) with relative maturity of a particular measure. The dependence of the GH effect on relative maturity suggests that different craniofacial morphologies may result depending on the timing of GH supplementation therapy. Anat Rec Part A 278A:561–570, 2004. © 2004 Wiley‐Liss, Inc.