Running-induced testicular recrudescence in the meadow vole: role of the circadian system.
Running-induced testicular recrudescence in the meadow vole: role of the circadian system.
复制标题
草地田鼠跑步引起的睾丸复发：昼夜节律系统的作用。
DOI：
10.1016/0031-9384(95)02244-9
复制
发表时间：
1996
影响因子：
2.9
通讯作者：
Bronson,FH
中科院分区：
文献类型：
--
作者：
Kerbeshian,MC;Bronson,FH
接触跑轮会刺激草地田鼠的睾丸复发，而草地田鼠的生殖轴因白天较短而受到抑制。本实验探讨了跑步刺激生殖系统的机制。来自两个实验的结果表明，跑步专门作用于推翻短日长对性腺的抑制：接近跑轮对长日长饲养的草甸田鼠的睾丸没有刺激作用，而跑步对短日长饲养的草甸田鼠的睾丸的刺激程度与田鼠对光反应的繁殖反应的程度显著相关。第三个实验质疑跑步是否会改变生物钟，从而导致短日长光周期和光敏感期之间的重叠。事实证明并非如此：在持续黑暗中饲养的草甸田鼠，接触到旋转的轮子会刺激睾丸复发。两项实验表明，接近转轮不会改变松果体褪黑素含量的短白天分布，也不会改变松果体褪黑素含量在没有光线的情况下夜间上升的情况。最后，尽管这种差异不能归因于昼夜节律系统的差异，但有轮和不带轮的田鼠循环皮质酮水平的每日模式确实不同。总体而言，这些实验表明，跑步通过作用于光周期抑制褪黑素产生下游生殖的途径来刺激性腺复发。
Access to running wheels stimulates testicular recrudescence in meadow voles whose reproductive axes have been suppressed by short day lengths. The present experiments addressed the mechanism by which running stimulates the reproductive system. The results from two experiments suggest that running acts specifically to override the short day length suppression of the gonads: access to running wheels had no stimulatory effect on the testes of meadow voles housed in long day lengths, and the degree to which running stimulated the testes of meadow voles housed under short day lengths was significantly correlated with the degree to which the voles were reproductively photoresponsive. A third experiment queried whether running shifts the circadian clock in such a way as to cause an overlap between the short day length photoperiod and the period of sensitivity to light. This proved not to be the case: access to running wheels stimulated testicular recrudescence in meadow voles housed in constant darkness. Two experiments demonstrated that access to a running wheel did not alter short day length profiles of pineal melatonin content or the nocturnal rise in pineal melatonin content in the absence of light. Finally, daily patterns of circulating corticosterone levels did differ between voles with and without access to running wheels, although the difference could not be attributed to differences in the circadian system. Overall, these experiments suggest that running stimulates gonadal recrudescence by acting on the pathway by which photoperiod suppresses reproduction downstream of melatonin production.