Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
复制标题
苯巴比妥减少和增强 2-乙酰氨基芴诱导的大鼠肝癌发生。
作者：
C. Peraino;R. Fry;E. Staffeldt
研究了膳食苯巴比妥对饲喂2-乙酰氨基荧烯(AAF)大鼠肝癌发生的影响。同时给予AAF和苯巴比妥可降低AAF的致癌作用。相比之下，AAF和苯巴比妥的顺序喂养导致了肝癌发病率的显著增加。单独饲喂苯巴比妥的大鼠未观察到不良反应。AAF和苯巴比妥均可刺激肝细胞增殖，但AAF的作用持续时间较长，而苯巴比妥的作用较短。苯巴比妥与AAF同时加入可降低AAF对肝细胞增殖的影响。
Summary The effects of dietary phenobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The simultaneous feeding of AAF and phenobarbital reduced the hepatocarcinogenic effects of AAF. In contrast, the sequential feeding of AAF and phenobarbital resulted in a significant increase in the incidence of hepatomas. No ill effects were observed in rats fed phenobarbital alone. AAF and phenobarbital each stimulated the proliferation of hepatocytes, but, whereas the effect of AAF was maintained for the duration of exposure, the effect of phenobarbital was short lived. Phenobarbital fed simultaneously with AAF decreased the effect of AAF on liver cell proliferation.