Modulation of cell adhesion by modification of titanium surfaces with covalently attached self-assembled monolayers.
Modulation of cell adhesion by modification of titanium surfaces with covalently attached self-assembled monolayers.
复制标题
通过共价连接的自组装单层修饰钛表面来调节细胞粘附。
DOI：
10.1002/jbm.820241004
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Merritt,K
中科院分区：
文献类型：
--
作者：
Sukenik,CN;Balachander,N;Culp,LA;Lewandowska,K;Merritt,K
钛的表面已被改性通过共价连接的有机单分子层由硅氧烷网络锚定。该涂层完全覆盖金属，并允许通过单层形成表面活性剂的暴露化学端基对表面性质进行可控改性。这种膜的附着允许不同的散装材料（例如，玻璃和钛）具有相同的表面性质，这可用于调节细胞粘附反应。这种对表面功能的控制可以调节纤连蛋白在调节神经元细胞的附着和神经突形成中的功能。还评估了通过使用这种单层来改变表面亲水性对细菌粘附的影响。
The surface of titanium has been modified by covalent attachment of an organic monolayer anchored by a siloxane network. This coating completely covers the metal and allows controlled modification of surface properties by the exposed chemical end‐groups of the monolayer forming surfactant. The attachment of such a film allows different bulk materials (e.g., glass and titanium) to have identical surface properties and this can be used in regulating cell adhesion responses. This control over surface functionality can modulate the functions of fibronectin in regulating attachment and neurite formation by neuronal cells. The effect on bacterial adherence that is achieved by using such monolayers to vary surface hydrophilicity is also assessed.