Tenascin-W: An extracellular matrix protein associated with osteogenesis and cancer
Tenascin-W: An extracellular matrix protein associated with osteogenesis and cancer
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DOI：
10.1016/j.biocel.2010.06.004
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发表时间：
2010-09-01
影响因子：
4
通讯作者：
Brellier, Florence
中科院分区：
文献类型：
--
作者：
Martina, Enrico;Chiquet-Ehrismann, Ruth;Brellier, Florence
Tenascin-W是已发现的四大细胞外基质糖蛋白家族中的最后一个成员。Tenascin家族的原始成员Tenascin-C因其与哮喘、纤维化、感染、炎症和癌症的关系而被广泛研究。最近的研究报道了Tenascin-W和Tenascin-C在结构、表达和功能方面的许多共同特征，特别是在肿瘤发生的背景下。此外，还揭示了Tenascin-W在成骨过程中的特殊功能。这篇综述介绍了我们目前关于Tenascin-W的最新知识，并讨论了这种富含癌症的细胞外基质蛋白的潜在医学应用。(C)2010爱思唯尔有限公司。保留所有权利。
Tenascin-W was the last member of a family of four large extracellular matrix glycoproteins to be discovered. The original member of the tenascin family, tenascin-C, has been widely studied due to its association with asthma, fibrosis, infection, inflammation and cancer. Recent studies report multiple common features between tenascin-W and tenascin-C in terms of structure, expression and function, especially in the context of tumorigenesis. Furthermore, specific functions for tenascin-W in osteogenesis have been revealed. This review presents an update on our current knowledge concerning tenascin-W and discusses potential medical applications of this cancer-enriched extracellular matrix protein. (C) 2010 Elsevier Ltd. All rights reserved.