Targeting ischemic penumbra Part II: selective drug delivery using liposome technologies.
Targeting ischemic penumbra Part II: selective drug delivery using liposome technologies.
复制标题
靶向缺血半暗带第二部分：使用脂质体技术选择性药物递送。
DOI：
10.6030/1939-067x-4.1.16
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Winn HR
中科院分区：
文献类型：
--
作者：
Liu S;Levine SR;Winn HR
在本综述（第二部分）中，我们讨论了脂质体技术选择性给药缺血脑组织的挑战和承诺。在本系列综述的第一部分中，我们提出了“选择性药物输送到缺血性脑组织”作为急性缺血性卒中的神经保护治疗技术。药物必须通过一系列的屏障才能到达缺血的脑组织才能发挥作用。脑缺血导致缺血区域的代谢和结构变化，这导致药物递送的额外障碍。脂质体药物传递系统可以通过这些屏障，并利用缺血引起的代谢和分子结构的变化，选择性地靶向缺血组织。
In the present review (part II), we discuss the challenges and promises of selective drug delivery to ischemic brain tissue by liposome technologies. In part I of this serial review, we proposed “selective drug delivery to ischemic brain tissue” as a technique for neuroprotective treatment of acute ischemic stroke. To be effective, drugs must pass a series of barriers to arrive at ischemic brain. Brain ischemia results in metabolic and structural changes in the ischemic region, which cause additional obstacles for drug delivery. Liposome drug delivery system can pass these barriers and selectively target ischemic tissue by utilizing ischemia-induced changes in metabolism and molecular structure.