Analysis of cerebrospinal fluid inflammatory mediators in chronic complex regional pain syndrome related dystonia
Analysis of cerebrospinal fluid inflammatory mediators in chronic complex regional pain syndrome related dystonia
复制标题
DOI：
10.1097/ajp.0b013e318156d961
复制
发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
van Hilten, Jacobus J.
中科院分区：
文献类型：
--
作者：
Munts, Alexander G.;Zijlstra, Freek J.;van Hilten, Jacobus J.
目的：有令人信服的证据表明，中枢神经系统参与神经性疼痛和运动障碍的患者与复杂的区域疼痛综合征（CRPS）。以前，在有和没有运动障碍的CRPS患者中发现了脑脊液（CSF）中白细胞介素-1 β和白细胞介素-6水平升高。本研究的目的是复制这些研究结果，并寻找额外的CSF生物标志物在慢性CRPS患者肌张力障碍。方法：CSF样本的20例患者和29例对照进行脊髓麻醉手术干预参与。我们检测了白细胞介素-1 β、白细胞介素-6、干扰素-γ诱导蛋白-10、RANTES（在活化时调节，正常T细胞表达和分泌）、补体C3、甘露糖结合凝集素、补体Clq、可溶性细胞间粘附分子-1、内皮素-1、一氧化氮、人乳铁蛋白和下丘脑泌素-1水平。患者和对照组之间的CSF中这些效应介质的水平没有差异被发现。结论：我们的CSF研究结果不支持各种炎症介质或下丘脑泌素-1在慢性CRPS患者肌张力障碍的作用。
Objectives: There is compelling evidence of central nervous system involvement in neuropathic pain and movement disorders in patients with complex regional pain syndrome (CRPS). Previously, elevated cerebrospinal fluid (CSF) levels of interleukin-1 beta and interleukin-6 were found in CRPS patients with and without movement disorders. The aim of the present study was to replicate these findings and to search for additional CSF biomarkers in chronic CRPS patients with dystonia.Methods: CSF samples of 20 patients and 29 controls who underwent spinal anesthesia for surgical interventions participated. We measured interleukin-1 beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement Clq, soluble intercellular adhesion molecule-1 endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.Results: No differences in the CSF levels of these effector mediators between patients and controls were found.Conclusion: Our CSF findings do not support a role of a variety of inflammatory mediators or hypocretin-1 in chronic CRPS patients with dystonia.