CLONING OF A T-CELL GROWTH-FACTOR THAT INTERACTS WITH THE BETA-CHAIN OF THE INTERLEUKIN-2 RECEPTOR
CLONING OF A T-CELL GROWTH-FACTOR THAT INTERACTS WITH THE BETA-CHAIN OF THE INTERLEUKIN-2 RECEPTOR
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DOI：
10.1126/science.8178155
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发表时间：
1994-05-13
期刊：
影响因子：
56.9
通讯作者：
GIRI, JG
中科院分区：
文献类型：
--
作者：
GRABSTEIN, KH;EISENMAN, J;GIRI, JG
我们发现了一种细胞因子可以刺激T淋巴细胞的增殖，并分离出一种编码这种新的T细胞生长因子的互补DNA克隆。这种细胞因子被称为白介素-15 (IL-15)，由多种细胞和组织产生，并与IL-2具有许多生物学特性。IL-2受体β链的单克隆抗体抑制IL-15的生物活性，IL-15与IL-2竞争结合，表明IL-15利用IL-2受体的成分。
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.