Dopaminergic signaling within the primary cilia in the renovascular system.
Dopaminergic signaling within the primary cilia in the renovascular system.
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DOI：
10.3389/fphys.2015.00103
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发表时间：
2015
影响因子：
4
通讯作者：
Nauli SM
中科院分区：
文献类型：
--
作者：
Atkinson KF;Kathem SH;Jin X;Muntean BS;Abou-Alaiwi WA;Nauli AM;Nauli SM
已知多巴胺5型受体（DR5）的激活可降低全身血压，最可能是通过增加肾血管舒张和增强肾脏中的尿钠排泄。然而，DR5在尿钠排泄和血管舒张中的机制尚不清楚。我们以前已经表明，DR5是本地化的初级纤毛近端肾上皮细胞和血管内皮细胞。我们在这里表明，DR5的选择性激活特异性地诱导钙离子流入仅在初级纤毛，而多巴胺受体的非选择性激活诱导cilioplasm和细胞质中的钙通量。凝血酶诱导的纤毛非依赖性信号传导仅显示细胞质内的钙信号传导。此外，DR5在纤毛质中的钙激活增加了初级纤毛的长度和机械感觉功能，导致对流体剪切应力的更大响应。因此，我们提出了一种新的机制，DR5诱导血管舒张通过化学和机械性能，是特定的初级纤毛。
Activation of dopamine receptor type-5 (DR5) has been known to reduce systemic blood pressure, most likely by increasing renal vasodilation and enhancing natriuresis in the kidney. However, the mechanism of DR5 in natriuresis and vasodilation was not clearly known. We have previously shown that DR5 is localized to primary cilia of proximal renal epithelial and vascular endothelial cells. We here show that selective activation of DR5 specifically induces calcium influx only in the primary cilia, whereas non-selective activation of dopamine receptor induces calcium fluxes in both cilioplasm and cytoplasm. Cilia-independent signaling induced by thrombin only shows calcium signaling within cytoplasm. Furthermore, calcium activation in the cilioplasm by DR5 increases length and mechanosensory function of primary cilia, leading to a greater response to fluid-shear stress. We therefore propose a new mechanism by which DR5 induces vasodilation via chemical and mechanical properties that are specific to primary cilia.
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影响因子：
2.5
作者：
Kathem, Sarmed H.;Mohieldin, Ashraf M.;Nauli, Surya M.
通讯作者：
Nauli, Surya M.
DOI：
10.1161/hypertensionaha.111.172080
发表时间：
2011-08
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Abdul-Majeed S;Nauli SM
通讯作者：
Nauli SM
影响因子：
13.6
作者：
Nauli, Surya M.;Rossetti, Sandro;Zhou, Jing
通讯作者：
Zhou, Jing
影响因子：
6.1
作者：
Verghese, Elizabeth;Weidenfeld, Raphael;Deane, James A.
通讯作者：
Deane, James A.
DOI：
10.1097/01.asn.0000029587.47950.25
发表时间：
2002-10-01
影响因子：
13.6
作者：
Yoder, BK;Hou, XY;Guay-Woodford, LM
通讯作者：
Guay-Woodford, LM