Effect of testosterone cypionate on postexercise ST segment depression.
Effect of testosterone cypionate on postexercise ST segment depression.
复制标题
环戊丙酸睾酮对运动后 ST 段压低的影响。
作者：
M. Jaffe
对50名在改良两步运动试验后ST段压低0.1 mV或以上的男性进行了随机双盲研究。在每周肌肉注射200毫克的安慰剂或睾丸酮治疗4周和8周后，每名受试者的最后几次预处理测试的运动率和持续时间与他的测试相同。安慰剂治疗4周和8周后，即刻、运动后2、4和6分钟的II、V4、V5和V6导联ST段压低总和无明显变化，但分别在治疗4周和8周后下降32%(P<0.0001)和51%(P<0.0001)。睾丸激素治疗导致运动后ST段压低减轻的机制尚不明确。
A randomised double blind study was carried out with 50 men who had ST segment depression of 0.1 mV or more after a modified two-step exercise test. Rate and duration of exercise were the same for the last of each subject's several pretreatment tests as for his tests after 4 and 8 weeks of treatment with placebo or testosterone cypionate, 200 mg, intramuscularly weekly. The sum of ST segment depression in leads II, V4, V5, and V6 taken immediately, and 2, 4, and 6 minutes after exercise did not change significantly after 4 or 8 weeks of placebo treatment, but did decrease by 32 per cent (P less than 0.0001) and 51 per cent (P less than 0.0001) after 4 and 8 weeks, respectively, of testosterone cypionate treatment. The mechanism by which testosterone cypionate treatment results in lessened postexercise ST segment depression is not established.