Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant.
Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant.
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DOI：
10.1016/j.clinthera.2016.01.006
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发表时间：
2016-04
影响因子：
3.2
通讯作者：
Underwood MA
中科院分区：
文献类型：
--
作者：
Vongbhavit K;Underwood MA
尽管经过四十年的研究，坏死性小肠结肠炎（NEC）仍然是早产儿最常见的胃肠道并发症，具有高死亡率和长期发病率。早产儿的肠道微生物群的组成与健康足月儿的肠道微生物群的组成显著不同，并且似乎是NEC的重要风险因素。改变肠道微生物群的有希望的NEC预防策略包括益生菌，益生元，合生元，乳铁蛋白和母乳喂养。
In spite of four decades of research, necrotizing enterocolitis (NEC) remains the most common gastrointestinal complication in premature infants with high mortality and long-term morbidity. The composition of the intestinal microbiota of the premature infant differs dramatically from that of the healthy term infant and appears to be an important risk factor for NEC. Promising NEC prevention strategies that alter the intestinal microbiota include probiotics, prebiotics, synbiotics, lacteroferrin, and human milk feeding.