Comparison of the Suppression of Interferon Production and Inhibition of Its Action by Vitamin A and Related Compounds
Comparison of the Suppression of Interferon Production and Inhibition of Its Action by Vitamin A and Related Compounds
复制标题
维生素A及相关化合物抑制干扰素产生及其作用的比较
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
G. Gifford
中科院分区：
文献类型：
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作者：
J. Blalock;G. Gifford
摘要我们研究了维生素A抑制干扰素产生和抑制干扰素作用的结构要求。干扰素作用的抑制似乎最依赖于维生素A分子的侧链。侧链显然需要共轭双键系统和亲氢末端基团来抑制干扰素的作用。相比之下，维生素A分子的环部分似乎对抑制干扰素的产生最为重要。
Summary We have investigated the structural requirements for vitamin A suppression of interferon production and inhibition of interferon action. Inhibition of interferon action seems to be most dependent on the side chain of the vitamin A molecule. The side chain apparently requires a conjugated double bond system and a hy-drophilic terminal group to inhibit interferon action. In contrast, the ring portion of the vitamin A molecule seems to be most important for the suppression of interferon production.