Serum IgA tissue transglutaminase antibodies in coeliac disease and other gastrointestinal diseases
Serum IgA tissue transglutaminase antibodies in coeliac disease and other gastrointestinal diseases
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DOI：
10.1093/qjmed/94.4.195
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发表时间：
2001-04-01
影响因子：
13.3
通讯作者：
Ghosh, S
中科院分区：
文献类型：
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作者：
Dahele, AVM;Aldhous, MC;Ghosh, S
我们研究了未经治疗的乳糜泻 (CD) 和其他胃肠道疾病中 IgA 抗组织转谷氨酰胺酶 (tTG) 抗体的存在，并将 IgA tTG 浓度与抗肌内膜 (EMA) 免疫荧光结果进行了比较。该研究包括 116 名未经治疗的 CD 患者（74 名女性，42 名男性，年龄范围 15-78 岁，中位年龄 47 岁）、82 名接受治疗的 CD 患者、65 名十二指肠组织学正常的患者、260 名疾病对照样本和 29 名健康志愿者。测量了 IgA 抗 tTG、EMA 和抗麦醇溶蛋白 (ACA) 抗体。测量 CD 患者的血清总 IgA。两名 IgA 缺乏且未经治疗的 CD 患者被排除在外。在 114 名未经治疗的 CD 患者中，IgA EMA 和 IgA AGA 分别有 99 69 名 (61%) 呈阳性。在 92/114 (81%) 未经治疗的乳糜泻患者、1/82 (1%) 接受治疗的乳糜泻患者、2/65 (3%) 非乳糜泻患者、10/260 (4%) 疾病对照者和 2/29 (7%) 志愿者中发现 IgA 抗 tTG 升高。 4 名未经治疗的 CD 患者血清总 IgA 浓度正常，所有血清学检测均为阴性。未经治疗的乳糜泻患者的 IgA 抗 tTG 浓度（中位数 10 200 单位/毫升）显着高于其他组（Mann-Whitney，p
We investigated the presence of IgA anti-tissue transglutaminase (tTG) antibodies in untreated coeliac disease (CD) and other gastrointestinal diseases, and compared IgA tTG concentrations with anti-endomysium (EMA) immunofluorescent findings. The study included 116 untreated CD patients (74 female, 42 male, age range 15-78 years, median 47 years), 82 treated CD patients, 65 patients with normal duodenal histology, 260 disease control samples and 29 healthy volunteers. IgA anti-tTG, EMA, and anti-gliadin (ACA) antibodies were measured. Serum total IgA was measured in the CD patients. Two IgA-deficient untreated CD patients were excluded. IgA EMA and IgA AGA were positive in 99 69 (61%), respectively, of the 114 untreated CD patients. Elevated IgA anti-tTG were found in 92/114 (81%) untreated coeliacs, 1/82 (1%) treated coeliacs, 2/65 (3%) non-coeliacs, 10/260 (4%) disease controls and 2/29 (7%) volunteers. Four of the untreated CD patients, with a normal serum total IgA concentration, were negative for all the serological tests. IgA anti-tTG concentrations were significantly higher in untreated coeliacs (median 10 200 units/ml) than in other groups (Mann-Whitney, p