Effect of interseed spacing, tissue perfusion, thermoseed temperatures and catheters in ferromagnetic hyperthermia: results from simulations using finite element models of thermoseeds and catheters.
Effect of interseed spacing, tissue perfusion, thermoseed temperatures and catheters in ferromagnetic hyperthermia: results from simulations using finite element models of thermoseeds and catheters.
复制标题
铁磁热疗中种子间距、组织灌注、热种子温度和导管的影响：使用热种子和导管的有限元模型进行模拟的结果。
DOI：
10.1109/10.324530
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Paliwal,BR
中科院分区：
文献类型：
--
作者：
Tompkins,DT;Vanderby,R;Klein,SA;Beckman,WA;Steeves,RA;Paliwal,BR
开发了铁磁热种子和导管的有限元传热模型，用于模拟铁磁热疗。这些模型被实施到通用有限元计算机程序中，以求解生物传热方程。种子和导管模型的独特之处在于，它们比其他先前开发的热模型具有更少的建模约束。在多室组织模型中使用 4/spl 次/4 阵列的种子进行模拟。传热模型预测，当种子温度取决于功率时，与假设种子温度恒定的模型相比，大于 43/spl deg/C 的肿瘤比例会降低 8% 到 40%。在使用种子和导管模型的模拟中，大于 42/spl deg/C 的肿瘤分数比使用裸种子的模拟低 3.3% 至 25%。结果表明，在几乎所有研究的血液灌注病例中，居里点为 62.6/spl deg/C 的一系列种子可以很好地加热肿瘤。总之，本文的结果表明，模拟铁磁热疗的热模型应考虑种子的功率-温度依赖性，并包括导管的显式模型。< >
Finite element heat-transfer models of ferromagnetic thermoseeds and catheters are developed for simulating ferromagnetic hyperthermia, These models are implemented into a general purpose, finite element computer program to solve the bioheat transfer equation. The seed and catheter models are unique in that they have fewer modeling constraints than other previously developed thermal models. Simulations are conducted with a 4/spl times/4 array of seeds in a multicompartment tissue model. The heat transfer model predicts that fractions of tumor greater than 43/spl deg/C are between 8 and 40% lower when seed temperatures depend on power versus models which assume a constant seed temperature. Fractions of tumor greater than 42/spl deg/C, in simulations using seed and catheter models, are between 3.3 and 25% lower than in simulations with bare seeds. It is demonstrated that an array of seeds with Curie points of 62.6/spl deg/C heats the tumor very well over nearly all blood perfusion cases studied. In summary, results herein suggest that thermal models simulating ferromagnetic hyperthermia should consider the power-temperature dependence of seeds and include explicit models of catheters.< >