Oxidative stress in smokers and non-smokers
Oxidative stress in smokers and non-smokers
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DOI：
10.1080/08958370701401418
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Isik, Recep
中科院分区：
文献类型：
--
作者：
Isik, Birgul;Ceylan, Ali;Isik, Recep
氧化应激在肺癌、慢性阻塞性肺疾病、动脉粥样硬化等疾病的发病机制中起重要作用。吸烟不仅可能通过产生烟雾中的活性氧自由基，而且还可能通过削弱抗氧化防御系统来增强氧化应激。在这项研究中，我们调查了吸烟对健康人群中脂质过氧化和对氧磷酶活性的影响。这项研究包括(30)吸烟者和(30)不吸烟者。研究人群的年龄为44.74±10.59岁。血清丙二醛(MDA)和对氧磷酶(PON1)活性分别用改良Buege法和Eckerson法测定。数据分析采用学生t检验。血清丙二醛水平显著升高(P<0.05)。
Oxidative stress plays an important role in the pathogenesis of some diseases such as lung cancer, chronic obstructive pulmonary disease, and atheroscleorosis. Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through weakening of the antioxidant defense systems. In this study, we investigated the effects of smoking on lipid peroxidation and paraoxonase activity in a healthy population. The study consisted of (n = 30) smokers and (n = 30) nonsmokers. The age of the population which is studied was 44.74 +/- 10.59 yr. The levels of serum malondialdehyde (MDA) and paraoxonase (PON1) activities were measured by the modified Buege method and the Eckerson method, respectively. Student's t-test was used to analyze the data. The serum MDA levels were significantly higher (p