Early Treatment of a Migraine Attack while Pain is Still Mild Increases the Efficacy of Sumatriptan
Early Treatment of a Migraine Attack while Pain is Still Mild Increases the Efficacy of Sumatriptan
复制标题
在疼痛仍然轻微时早期治疗偏头痛发作可提高舒马曲坦的疗效
DOI：
10.1111/j.1468-2982.2004.00802.x
复制
发表时间：
2004
期刊：
影响因子：
4.9
通讯作者：
N. Banik
中科院分区：
文献类型：
--
作者：
J. Scholpp;R. Schellenberg;B. Moeckesch;N. Banik
为了调查这样的假设：与疼痛至少为中度时的延迟治疗相比，在疼痛仍然轻微的情况下早期使用舒马曲坦治疗偏头痛发作会产生更高的无痛率，我们进行了一项前瞻性、对照和开放标签研究。符合国际头痛协会推荐的诊断标准的有或无先兆偏头痛患者被纳入该研究，并被随机分配接受“早期”或“晚期”舒马曲坦 100 毫克片剂治疗。在早期治疗组中，与晚期治疗组相比，在给药后两小时内测量的所有时间段内始终无疼痛的患者明显更多。此外，早期治疗组的患者在给药后明显比延迟治疗的患者更快地摆脱疼痛。结论是，能够区分偏头痛发作和其他形式头痛的偏头痛患者可以从舒马普坦 100 毫克片剂的早期干预中受益。
To investigate the hypothesis that early treatment of a migraine attack with sumatriptan, while pain is still mild, results in higher pain free rates in comparison to delayed treatment, when pain is at least moderate, we performed a prospective, controlled and open label study. Migraineurs with or without aura who fulfilled the diagnostic criteria recommended by the International Headache Society were enrolled in the study and randomly assigned to either ‘early’ or ‘late’ treatment with sumatriptan 100 mg tablets. In the early treatment group significantly more patients were pain free at all times measured during two hours after dosing than in the late treatment group. Furthermore, patients in the early treatment group became pain free significantly sooner after dosing than patients who delayed treatment. It is concluded that migraineurs, who are able to differentiate between a migraine attack and other forms of headache, benefit from early intervention with sumatriptan 100 mg tablets.
影响因子：
14.5
作者：
Burstein, R;Cutrer, MF;Yarnitsky, D
通讯作者：
Yarnitsky, D