The imide tautomer of sulfasalazine
The imide tautomer of sulfasalazine
复制标题
DOI：
10.1107/s0108270104003026
复制
发表时间：
2004-04-01
影响因子：
0.8
通讯作者：
Yuan, RX
中科院分区：
文献类型：
--
作者：
Blake, AJ;Lin, X;Yuan, RX
标题化合物5-{4-[（2-吡啶亚基氨基）磺酰基]苯基二氮烯基}水杨酸，C18 H14 N4 O 5S，为酰亚胺互变异构体，单斜晶系P2（1）/c。除了一个分子内的OH... O氢键分子间O-H键O相互作用将相邻分子连接成螺旋，螺旋通过成对的N-H连接. N相互作用成二维氢键层。分子构象和堆积均不同于三斜酰胺形式[Filip等人（2001）。Acta Cryst.C57，435 - 436]。
The title compound, 5-{4-[(2-pyridylideneamino) sulfonyl]phenyldiazenyl} salicylic acid, C18H14N4O5S, crystallizes as the imide tautomer in the monoclinic space group P2(1)/c. In addition to an intramolecular O-H...O hydrogen bond, intermolecular O-H...O interactions link adjacent molecules into helices, which are connected by pairwise N-H...N interactions into two-dimensional hydrogen-bonded layers. Both the molecular conformation and the packing differ from those seen in the triclinic amide form [Filip et al. (2001). Acta Cryst. C57, 435 - 436].