The role of the CDCA gene family in ovarian cancer
The role of the CDCA gene family in ovarian cancer
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DOI：
10.21037/atm.2020.01.99
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发表时间：
2020-03-01
影响因子：
--
通讯作者：
Li, Huan
中科院分区：
文献类型：
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作者：
Chen, Chongxiang;Chen, Siliang;Li, Huan
背景：卵巢癌是一种常见于女性生殖系统的恶性肿瘤，每年在世界范围内导致超过10万人死亡。方法：使用GEPIA、ONCOMINE、metscape和Kaplan-Meier Plotter等电子数据库，对卵巢癌患者细胞分裂周期相关（CDCA）基因家族的生存和转录数据进行检测。结果：CDCA基因在卵巢癌组织中的表达水平均高于非癌性卵巢组织。此外，CDCA5/7表达水平与肿瘤晚期有关。此外，采用Kaplan-Meier Plotter数据库进行生存分析，结果提示CDCA2/3/5/7表达水平升高的卵巢癌患者总生存期（OS）较差(P
Background: Ovarian cancer is a frequently-occurring reproductive system malignancy in females, which leads to an annual of over 100 thousand deaths worldwide.Methods: The electronic databases, including GEPIA, ONCOMINE, Metascape, and Kaplan-Meier Plotter, were used to examine both survival and transcriptional data regarding the cell division cycle associated (CDCA) gene family among ovarian cancer patients.Results: All CDCA genes expression levels were up-regulated in ovarian cancer tissues relative to those in non-carcinoma ovarian counterparts. Besides, CDCA5/7 expression levels were related to the late tumor stage. In addition, the Kaplan-Meier Plotter database was employed to carry out survival analysis, which suggested that ovarian cancer patients with increased CDCA2/3/5/7 expression levels had poor overall survival (OS) (P