Aging of Skeletal Stem Cells.
Aging of Skeletal Stem Cells.
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DOI：
10.20900/agmr20220006
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发表时间：
2022-01-01
期刊：
影响因子：
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通讯作者：
Chan, Charles K F
中科院分区：
文献类型：
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作者：
Butler, M Gohazrua K;Ambrosi, Thomas H;Chan, Charles K F
骨骼系统是由其祖细胞，骨骼干细胞（SSC），在整个生命周期中产生和维持的。与衰老相关的逐渐变化导致SSC功能的显著差异。骨骼和软骨生成的下降、骨髓脂肪组织的增加、细胞微环境的组成变化以及随后的外部和内部结构的恶化最终导致骨骼老化和衰弱。骨骼衰老的特征和机制，特别是其干细胞和祖细胞的特征和机制，是最近研究的主题。具有确定的细胞表面表型的功能同质的SSC群体的发现允许在其对转录调控、细胞功能和身份的影响方面更仔细地检查衰老。在这里，我们回顾了微观和宏观层面上的SSC老化方面。介绍了SSC生物学和衰老的最新知识，并讨论了未来研究和潜在疗法的方向。SSC介导的骨衰老领域仍然是全球健康的重要组成部分，也是我们理解人类衰老的必要方面。
The skeletal system is generated and maintained by its progenitors, skeletal stem cells (SSCs), across the duration of life. Gradual changes associated with aging result in significant differences in functionality of SSCs. Declines in bone and cartilage production, increase of bone marrow adipose tissue, compositional changes of cellular microenvironments, and subsequent deterioration of external and internal structures culminate in the aged and weakened skeleton. The features and mechanisms of skeletal aging, and of its stem and progenitor cells in particular, are topics of recent investigation. The discovery of functionally homogeneous SSC populations with a defined cell surface phenotype has allowed for closer inspection of aging in terms of its effects on transcriptional regulation, cell function, and identity. Here, we review the aspects of SSC aging on both micro- and macroscopic levels. Up-to-date knowledge of SSC biology and aging is presented, and directions for future research and potential therapies are discussed. The realm of SSC-mediated bone aging remains an important component of global health and a necessary facet in our understanding of human aging.