Calreticulin: roles in cell-surface protein expression.
Calreticulin: roles in cell-surface protein expression.
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DOI：
10.3390/membranes4030630
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发表时间：
2014-09-16
期刊：
影响因子：
4.2
通讯作者：
Matsunami H
中科院分区：
文献类型：
--
作者：
Jiang Y;Dey S;Matsunami H
为了执行其指定的功能，蛋白质需要精确的亚细胞定位。对于细胞表面蛋白质，如受体和通道，它们只有在正确靶向细胞膜时才能传递信号。钙网蛋白是一种参与蛋白质折叠、成熟和运输的多功能伴侣蛋白。然而，越来越多的证据表明钙网蛋白也可以负调节某些受体和通道的表面表达。在这些情况下，钙网蛋白的消耗增强细胞表面表达和功能。在这篇综述中，我们讨论了钙网蛋白的作用，重点是其对细胞表面蛋白表达的负面影响。
In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane. Calreticulin is a multi-functional chaperone protein involved in protein folding, maturation, and trafficking. However, evidence has been accumulating that calreticulin can also negatively regulate the surface expression of certain receptors and channels. In these instances, depletion of calreticulin enhances cell-surface expression and function. In this review, we discuss the role of calreticulin with a focus on its negative effects on the expression of cell-surface proteins.