Traditional medicinal use is linked with apparency, not specialized metabolite profiles in the order Caryophyllales
Traditional medicinal use is linked with apparency, not specialized metabolite profiles in the order Caryophyllales
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DOI：
10.1002/ajb2.16308
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发表时间：
2024-04-05
影响因子：
3
通讯作者：
Yang，Ya
中科院分区：
文献类型：
--
作者：
Crum，Alex H.;Philander，Lisa;Yang，Ya
更好地了解植物专门代谢和传统医学之间的关系，有可能有助于生物勘探和跨文化使用模式的解开。然而，鉴于大多数植物物种中代谢物的信息有限，理解药用代谢物的关系可能很困难。该命令Carlellales有一个独特的模式的谱系酪氨酸或苯丙氨酸为主的专门代谢，由相互排斥的花青素和甜菜色素色素的代表，使Carlellales一个引人注目的系统，探索药物和代谢物之间的关系，通过使用色素作为代理优势代谢。方法我们编制了一份名单的药用物种在选择酪氨酸或苯丙氨酸为主的家庭Carlellales（猪笼草科、蓼科、西蒙得科、Microteaceae、石竹科、苋科、Limeaceae、柔枝花科、马齿苋科、仙人掌科和夜来香科）通过检索科学文献，直至未发现新用途。然后，我们使用“热点节点”方法测试了系统发育聚类。为了测试潜在的非代谢物药物使用驱动因素，例如人类遇到一个物种的频率（apparency），我们仅对整个目中的北美物种进行了重复分析，并对来自全球生物多样性信息设施（GBIF）的发生数据进行了系统发育广义最小二乘回归（PGLS）结果我们假设酪氨酸富集代谢的家庭与苯丙氨酸富集代谢相比，会显示不同类型的药物使用的聚类。相反，广泛的，明显的亚科在Polygonaceae和Amaranthaceae是过度代表在几乎所有类型的药用use.ConclusionsOur研究结果表明，apparency是一个更好的预测药物使用比代谢，虽然代谢类型可能仍然是一个贡献因素。
PremiseBetter understanding of the relationship between plant specialized metabolism and traditional medicine has the potential to aid in bioprospecting and untangling of cross‐cultural use patterns. However, given the limited information available for metabolites in most plant species, understanding medicinal use–metabolite relationships can be difficult. The order Caryophyllales has a unique pattern of lineages of tyrosine‐ or phenylalanine‐dominated specialized metabolism, represented by mutually exclusive anthocyanin and betalain pigments, making Caryophyllales a compelling system to explore the relationship between medicine and metabolites by using pigment as a proxy for dominant metabolism.MethodsWe compiled a list of medicinal species in select tyrosine‐ or phenylalanine‐dominant families of Caryophyllales (Nepenthaceae, Polygonaceae, Simmondsiaceae, Microteaceae, Caryophyllaceae, Amaranthaceae, Limeaceae, Molluginaceae, Portulacaceae, Cactaceae, and Nyctaginaceae) by searching scientific literature until no new uses were recovered. We then tested for phylogenetic clustering of uses using a “hot nodes” approach. To test potential non‐metabolite drivers of medicinal use, like how often humans encounter a species (apparency), we repeated the analysis using only North American species across the entire order and performed phylogenetic generalized least squares regression (PGLS) with occurrence data from the Global Biodiversity Information Facility (GBIF).ResultsWe hypothesized families with tyrosine‐enriched metabolism would show clustering of different types of medicinal use compared to phenylalanine‐enriched metabolism. Instead, wide‐ranging, apparent clades in Polygonaceae and Amaranthaceae are overrepresented across nearly all types of medicinal use.ConclusionsOur results suggest that apparency is a better predictor of medicinal use than metabolism, although metabolism type may still be a contributing factor.