Thymus-homing dendritic cells in central tolerance
Thymus-homing dendritic cells in central tolerance
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DOI：
10.1002/eji.201243192
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发表时间：
2013-06-01
影响因子：
5.4
通讯作者：
Butcher, Eugene C.
中科院分区：
文献类型：
--
作者：
Hadeiba, Husein;Butcher, Eugene C.
中枢耐受对于建立清除功能性自身反应性T细胞的外周T细胞谱系至关重要。有效的中枢耐受的主要要求之一是将自身和其他无害抗原(AGs)，包括食物、肠道菌群或呼吸道过敏原，呈递给胸腺中正在发育的T细胞。这一看似具有挑战性的任务在某些情况下可以通过胸腺上皮细胞异位表达组织特异性AGS或通过全身血液传播的AGS进入胸腺来调节。最近，胸腺寄生的外周树突状细胞(DC)被认为是外周组织特异性AGS或外来无害AGS的细胞转运体。这一观点的目的是在中枢耐受的背景下讨论胸腺树突状细胞的三个主要群体及其运输特性。我们将首先讨论外周树突状细胞转运对胸腺的重要性，然后比较和对比三种DC亚群。我们将描述它们的特征，描述它们在胸腺中的运输和微环境定位，并讨论胸腺运输和定位对胸腺选择事件的功能影响。
Central tolerance is critical in establishing a peripheral T-cell repertoire purged of functional autoreactive T cells. One of the major requirements for effective central tolerance is the presentation of self and other innocuous antigens (Ags), including food, gut flora, or airway allergens, to developing T cells in the thymus. This seemingly challenging task can be mediated in some cases by ectopic expression of tissue-specific Ags by thymic epithelial cells or by entry of systemic blood-borne Ags into the thymus. More recently, thymic hom-ing peripheral dendritic cells (DCs) have been proposed as cellular transporters of peripheral tissue-specific Ags or foreign innocuous Ags. The aim of this viewpoint is to discuss the three principal thymic DC populations and their trafficking properties in the context of central tolerance. We will first discuss the importance of peripheral DC trafficking to the thymus and then compare and contrast the three DC subsets. We will describe how they were characterized, describe their trafficking to and their microenvironmental positioning in the thymus, and discuss the functional consequence of thymic trafficking and localization on thymic selection events.