MRI findings associated with development of incident knee pain over 48 months: data from the osteoarthritis initiative
MRI findings associated with development of incident knee pain over 48 months: data from the osteoarthritis initiative
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DOI：
10.1007/s00256-016-2343-5
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发表时间：
2016-05-01
影响因子：
2.1
通讯作者：
Link, Thomas M.
中科院分区：
文献类型：
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作者：
Joseph, Gabby B.;Hou, Stephanie W.;Link, Thomas M.
这项巢式病例对照研究的目的是确定基线，事件，标准MRI临床序列上可见的进展性MRI结果与48个月内OA风险受试者发生膝关节疼痛相关。我们分析了60例发生膝关节疼痛的病例（基线时WOMAC（疼痛）= 0，48个月时WOMAC（疼痛）为1/1000日元/5欧元）和60例对照膝关节（基线时WOMAC（疼痛）= 0，48个月时WOMAC（疼痛）= 0）。在基线和48个月后，使用改良的蠕虫评分（软骨、半月板、骨髓）分析3 T膝关节MRI。基线和纵向调查结果被分组到逻辑回归模型，并使用似然比检验进行比较。一个基线MRI结果和三个从基线到48个月变化的结果与疼痛的发展相关：在基线时，胫骨内侧软骨病变的严重程度与偶发疼痛相关（偶发疼痛的比值比（OR）= 3.05; P = 0.030）。从纵向看，（OR = 9.78; P = 0.005），髌骨进行性软骨病变（OR = 4.59; P = 0.009），以及内侧半月板撕裂事件（OR = 4.91; P = 0.028），但不包括在内。我们的研究结果表明，胫骨内侧软骨的基线异常以及关节积液、进行性髌骨软骨缺损和48个月内发生的内侧半月板撕裂可能与膝关节疼痛有关。临床上，这项研究有助于确定与膝关节疼痛发展相关的MRI结果。
The purpose of this nested case-control study was to identify baseline, incident, and progressive MRI findings visible on standard MRI clinical sequences that were associated with development of incident knee pain in subjects at risk for OA over a period of 48 months.We analyzed 60 case knees developing incident pain (WOMAC(pain) = 0 at baseline and WOMAC(pain) a parts per thousand yenaEuro parts per thousand 5 at 48 months) and 60 control knees (WOMAC(pain) = 0 at baseline and WOMAC(pain) = 0 at 48 months) from the Osteoarthritis Initiative. 3 T knee MRIs were analyzed using a modified WORMS score (cartilage, meniscus, bone marrow) at baseline and after 48 months. Baseline and longitudinal findings were grouped into logistic regression models and compared using likelihood-ratio tests. For each model that was significant, a stepwise elimination was used to isolate significant MRI findings.One baseline MRI finding and three findings that changed from baseline to 48 months were associated with the development of pain: at baseline, the severity of a cartilage lesion in the medial tibia was associated with incident pain-(odds ratio (OR) for incident pain = 3.05; P = 0.030). Longitudinally, an incident effusion (OR = 9.78; P = 0.005), a progressive cartilage lesion of the patella (OR = 4.59; P = 0.009), and an incident medial meniscus tear (OR = 4.91; P = 0.028) were associated with the development of pain.Our results demonstrate that baseline abnormalities of the medial tibia cartilage as well as an incident joint effusion, progressive patella cartilage defects, and an incident medial meniscus tear over 48 months may be associated with incident knee pain. Clinically, this study helps identify MRI findings that are associated with the development of knee pain.