Magnetic resonance perfusion and diffusion characteristics of granulomatous disease mimic those of malignant lesions: six case reports
Magnetic resonance perfusion and diffusion characteristics of granulomatous disease mimic those of malignant lesions: six case reports
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肉芽肿性疾病的磁共振灌注和扩散特征与恶性病变相似：六例报告
DOI：
10.1007/s11282-017-0271-2
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发表时间：
2018
期刊：
影响因子：
2.2
通讯作者：
Nakamura Takashi
中科院分区：
文献类型：
--
作者：
Sumi Misa;Takagi Yukinori;Sasaki Miho;Eida Sato;Katayama Ikuo;Hotokezaka Yuka;Nakamura Takashi
肿瘤的灌注和扩散特性是评估其生长潜力和预测其组织类型（如良性或恶性）的重要线索。在动态增强磁共振（MR）成像过程中，通过评估肿瘤内造影剂水平的随时间变化来估计肿瘤灌注，而在弥散加权磁共振成像中，通过评估肿瘤内水的弥散性来估计肿瘤扩散。肉芽肿性疾病有不同的病因，可发生在头颈部的各个部位，包括下颌骨、上颌窦、唾液腺和淋巴结。然而，头颈部肉芽肿疾病的灌注和扩散特性并没有很好的文献记载。在本研究中，我们评估了出现在头颈部软组织的6种不同组织学类型肉芽肿性疾病的时间信号强度曲线和表观扩散系数。我们的数据显示，肉芽肿性疾病的灌注和扩散特征与恶性疾病相似，强调需要仔细解释MR灌注和扩散结果，以区分肉芽肿性疾病和头颈部癌症。临床医生在解释影像学结果时应特别注意血液检查和活检结果。
The perfusion and diffusion properties of a tumor are important clues in evaluating its growth potential and predicting its histological type, such as benign or malignant. Tumor perfusion can be estimated by assessing time-dependent changes in the intratumoral levels of the contrast agent during dynamic contrast-enhanced magnetic resonance (MR) imaging, whereas tumor diffusion can be estimated by assessing intratumoral water diffusivity on diffusion-weighted MR imaging. Granulomatous diseases with different etiologies occur in various head and neck regions, including the mandible, maxillary sinus, salivary glands, and lymph nodes. However, the perfusion and diffusion properties of granulomatous diseases in the head and neck regions are not well documented. In this study, we assessed the time–signal intensity curves and apparent diffusion coefficients of six granulomatous diseases of various histological types that appeared in the soft tissues of the head and neck. Our data show that the perfusion and diffusion characteristics of granulomatous diseases mimic those of malignant diseases, highlighting the need for careful interpretation of MR perfusion and diffusion findings to distinguish between granulomatous diseases and cancers of the head and neck region. Clinicians should pay particular attention to blood examination and biopsy results when interpreting imaging findings.