Nevus cells in lymph nodes - An association with congenital cutaneous nevi
Nevus cells in lymph nodes - An association with congenital cutaneous nevi
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DOI：
10.1097/00000372-200202000-00001
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发表时间：
2002-02-01
影响因子：
1.1
通讯作者：
Walsh, N
中科院分区：
文献类型：
--
作者：
Fontaine, D;Parkhill, W;Walsh, N
众所周知，痣细胞的聚集可能发生在因各种原因切除的淋巴结的胶原框架中。这些可能很难与转移性癌症的淋巴结沉积物区分开来，但注意细胞学细节、细胞的分布及其免疫组织化学特征通常会得出令人满意的结论。从另一个角度来看，痣细胞在淋巴结中沉积的机制一直引起人们的兴趣和争议。这方面的理论包括细胞从皮肤痣到相应区域淋巴结的栓塞转移以及子宫内黑素细胞胚胎学迁移的畸变。文献中已初步表明淋巴结中痣细胞的存在与相应皮肤集水区的皮肤痣之间存在潜在联系。在评估黑色素瘤患者的前哨淋巴结的过程中，我们注意到相应皮肤区域中淋巴结痣和皮肤痣之间存在显着关联（Fischer 精确检验，p = 0.021）。与先天性皮肤痣的联系甚至更强（Fischer 精确检验，p = 0.008）。这巩固了以前关于这种关联的零星报告，通过进一步的审查可能有助于阐明结节性皮肤痣和先天性皮肤痣之间的联系机制。
It is known that collections of nevus cells can occur in the collagenous framework, of lymph nodes excised for a variety of reasons. These can be difficult to distinguish from nodal deposits of metastatic cancer but attention to cytologic detail, the distribution of the cells, and their immunohistochemical profile usually lead to a satisfactory conclusion. From another perspective, the mechanism by which nevus cells are deposited in lymph nodes has been a source of interest and controversy. Theories in this regard include embolic transfer of cells from cutaneous nevi to corresponding regional nodes and art aberration in the embryologic migration of melanocytes in utero. There have been tentative indications in the literature of a potential link between the presence of nevus cells in lymph nodes and cutaneous nevi in corresponding catchment areas of skin. In the course of evaluating sentinel lymph nodes from patients with melanoma, we noted a significant association between the presence of nodal nevi and cutaneous nevi in corresponding regional zones of skin (Fischer's exact test, p = 0.021). The link with cutaneous nevi of congenital type was even stronger (Fischer's exact test, p = 0.008). This consolidates previous sporadic reports of such an association and through further scrutiny may help shed light on the mechanism by which nodal and congenital cutaneous nevi are linked.