The structures of nonprotein-coding RNAs that drive internal ribosome entry site function.
The structures of nonprotein-coding RNAs that drive internal ribosome entry site function.
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DOI：
10.1002/wrna.1105
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发表时间：
2012-03
影响因子：
7.3
通讯作者：
Kieft, Jeffrey S.
中科院分区：
文献类型：
--
作者：
Plank, Terra-Dawn M.;Kieft, Jeffrey S.
内部核糖体进入位点(IRESS)是一种RNA序列，可以独立于信使RNA的5‘端招募翻译机制。在病毒和细胞RNA中都发现了IRES，它们对基因表达的调控很重要。IRESS用来招募核糖体的机制有很大的多样性，这反映在作为IRESS的各种RNA序列中。RNA序列作为IRES的能力是由从初级序列到动态RNP中的高阶三维结构在多个水平上工作的结构赋予的。当比较这些不同的结构时，一些趋势是明显的，但总体上不可能找到描述IRES结构和机制的普遍规则。显然，许多不同的序列和结构已经进化到执行招募、定位和激活核糖体的功能，而不使用典型的帽依赖机制。然而，随着我们对IRES功能背后的特定序列、结构和机制的了解的提高，可能会出现更多的共同特征来连接这些不同的RNA。
Internal Ribosome Entry sites (IRESs) are RNA sequences that can recruit the translation machinery independently of the 5′ end of the messenger RNA. IRESs are found in both viral and cellular RNAs and are important for regulating gene expression. There is great diversity in the mechanisms used by IRESs to recruit the ribosome and this is reflected in a variety of RNA sequences that function as IRESs. The ability of an RNA sequence to function as an IRES is conferred by structures operating at multiple levels from primary sequence through higher-order three-dimensional structures within dynamic RNPs. When these diverse structures are compared, some trends are apparent, but overall it is not possible to find universal rules to describe IRES structure and mechanism. Clearly, many different sequences and structures have evolved to perform the function of recruiting, positioning, and activating a ribosome without using the canonical cap-dependent mechanism. However, as our understanding of the specific sequences, structures, and mechanisms behind IRES function improves, more common features may emerge to link these diverse RNAs.
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在趋化应激后，BAG-1 IRES介导的翻译调节。
影响因子：
8
作者：
Dobbyn, H. C.;Hill, K.;Hamilton, T. L.;Spriggs, K. A.;Pickering, B. M.;Coldwell, M. J.;de Moor, C. H.;Bushell, M.;Willis, A. E.
通讯作者：
Willis, A. E.
影响因子：
5.4
作者：
Bieleski, L;Talbot, SJ
通讯作者：
Talbot, SJ
影响因子：
14.9
作者：
Easton, Laura E.;Locker, Nicolas;Lukavsky, Peter J.
通讯作者：
Lukavsky, Peter J.
影响因子：
56.9
作者：
Gilbert, Wendy V.;Zhou, Kaihong;Doudna, Jennifer A.
通讯作者：
Doudna, Jennifer A.
影响因子：
4.5
作者：
Costantino, D;Kieft, JS
通讯作者：
Kieft, JS