Gabapentin reduces the mechanosensitivity of fine afferent nerve fibres in normal and inflamed rat knee joints
Gabapentin reduces the mechanosensitivity of fine afferent nerve fibres in normal and inflamed rat knee joints
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DOI：
10.1016/s0304-3959(03)00043-5
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发表时间：
2003-07-01
期刊：
影响因子：
7.4
通讯作者：
McDougall, JJ
中科院分区：
文献类型：
--
作者：
Hanesch, U;Pawlak, M;McDougall, JJ
抗癫痫药物加巴喷丁已被证明具有抗痛觉过敏作用后，中央管理。这项电生理学研究是否外周给药加巴喷丁可以调节机械敏感性的初级传入神经支配正常和高岭土/角叉菜胶发炎大鼠膝关节。加巴喷丁（0.01，1和100毫克/公斤）的剂量依赖性减少传入放电率在正常和急性炎症大鼠膝关节的正常和过度旋转的反应。因此，除了其中枢作用模式之外，加巴喷丁的外周给药局部地减少伤害感受，并且这可以证明在治疗包括炎性关节炎的各种疼痛综合征中是有益的。(C)2003年国际疼痛研究协会。由Elsevier Science B. V.出版，版权所有。
The antiepileptic drug gabapentin has been shown to have an antihyperalgesic effect following central administration. This electrophysiological investigation examined whether peripherally administered gabapentin could modulate the mechanosensitivity of primary afferents innervating normal and kaolin/carrageenan inflamed rat knee joints. Close intraarterial injection of gabapentin (0.01, 1 and 100 mg/kg) dose-dependently reduced afferent firing rate in both normal and acutely inflamed rat knees in response to normal and hyperrotation of the joint. Thus, in addition to its central mode of action, peripheral administration of gabapentin reduces nociception locally and this may prove to be beneficial in the treatment of various pain syndromes including inflammatory arthritis. (C) 2003 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.