THE FUNCTIONAL-ANATOMY OF MIDDLE-LATENCY AUDITORY EVOKED-POTENTIALS - THALAMOCORTICAL CONNECTIONS
THE FUNCTIONAL-ANATOMY OF MIDDLE-LATENCY AUDITORY EVOKED-POTENTIALS - THALAMOCORTICAL CONNECTIONS
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DOI：
10.1152/jn.1992.68.2.425
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发表时间：
1992-08-01
影响因子：
2.5
通讯作者：
BARTH, DS
中科院分区：
文献类型：
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作者：
DI, S;BARTH, DS
1. 使用 8 X 8 通道微电极阵列绘制四只大鼠右侧顶颞新皮质 4.375 X 4.375 mm2 区域的上皮层场电位。通过双侧点击刺激和内侧膝状体腹侧和背侧部分的电刺激来诱发电位。2．皮层对点击刺激的反应复制了早期的发现。反应由初级听觉皮层区域（区域 41）中的正负双相波形（P1a 和 N1）和次级听觉皮层区域（区域 36）中的正单相波形（P1b）组成。两种电位模式，一种在 N1 潜伏期，另一种在 P1b 潜伏期，用于表示区域 41 和 36 内细胞的激活。这些模式的线性组合足以解释所有潜伏期诱发电位复合体的 90% 至 94% 的方差。 3．在相同的动物中，上皮层对内侧膝状体腹侧和背侧部分电刺激的反应也分别位于区域 41 和 36。来自这些单独刺激条件的电位模式的线性组合足以解释所有潜伏期下原始点击诱发电位复合体的 80% 至 93% 的方差。4．这些数据为解剖学上定义的丘脑皮质向初级和次级听觉皮层的投射提供了功能证据。他们认为短潜伏期皮质诱发电位（刺激后 10-60 毫秒）主要由 41 和 36 区的丘脑皮质平行激活主导。
1. An 8 X 8-channel microelectrode array was used to map epicortical field potentials from a 4.375 X 4.375-mm2 area in the right parietotemporal neocortex of four rats. Potentials were evoked with bilaterally presented click stimuli and with electrical stimulation of the ventral and dorsal divisions of the medial geniculate body.2. Epicortical responses to click stimuli replicated earlier findings. The responses consisted of a positive-negative biphasic waveform (P1a and N1) in the region of primary auditory cortex (area 41) and a positive monophasic waveform (P1b) in the region of secondary auditory cortex (area 36). Two potential patterns, one at the latency of the Nl and the other al the latency of the P1b, were used to represent activation of cells within areas 41 and 36. A linear combination of these patterns was sufficient to explain from 90 to 94% of the variance of the evoked potential complex at all latencies.3. In the same animals,epicortical responses to electrical stimulation of the ventral and dorsal divisions of the medial geniculate body were also localized to areas 41 and 36, respectively. A linear combination of potential patterns from these separate stimulation conditions was sufficient to explain from 80 to 93% of the variance of the original click-evoked potential complex at all latencies.4. These data provide functional evidence for anatomically defined topographical thalamocortical projections to primary and secondary auditory cortex. They suggest that short-latency cortical evoked potentials (10-60 ms poststimulus) are dominated by parallel thalamocortical activation of areas 41 and 36.