Sesquiterpenes from the fruits of Illicium jiadifengpi and their anti-hepatitis B virus activities
Sesquiterpenes from the fruits of Illicium jiadifengpi and their anti-hepatitis B virus activities
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DOI：
10.1016/j.fitote.2015.05.004
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发表时间：
2015-07-01
期刊：
影响因子：
3.4
通讯作者：
Zhang, Yan-Bing
中科院分区：
文献类型：
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作者：
Liu, Ji-Feng;Wang, Lei;Zhang, Yan-Bing
从加地风皮八角的果实中分离出两种新化合物，2S-羟基-加地芬内酯(1)和加地芬内酯酸(2)，以及八种已知化合物。使用多种光谱技术分析它们的结构，包括一维、二维核磁共振和 HR-ESI-MS 实验。通过 Hep G2.2.15 细胞系的 HBV 转染评估分离株的抗乙型肝炎病毒 (HBV) 活性。最活性化合物化合物4和5对HBeAg和HBsAg表达的抑制率在64.94μM和6135μM浓度下分别为28.85+/-3.15％和17.53+/-1.81％以及37.93+/-2.74％和23.47+/-9.52％。 (C) 2015 Elsevier B.V. 保留所有权利。
Two new compounds, 2S-hydroxyl-jiadifenolide (1) and jiadifenlactone acid (2), and eight known compounds were isolated from the fruits of Illicium jiadifengpi. Their structures were analysed using several spectroscopic techniques, including 1D-, 2D-NMR and HR-ESI-MS experiments. The anti-hepatitis B virus (HBV) activities of the isolates were evaluated via HBV transfection of the Hep G2.2.15 cell line. The inhibitory rates of the most active compounds, compounds 4 and 5, on the HBeAg and HBsAg expression were 28.85 +/- 3.15% and 17.53 +/- 1.81% and 37.93 +/- 2.74% and 23.47 +/- 9.52% at concentrations of 64.94 mu M and 6135 mu M, respectively. (C) 2015 Elsevier B.V. All rights reserved.