Palladium-catalyzed enantioselective 1,1-fluoroarylation of aminoalkenes.
Palladium-catalyzed enantioselective 1,1-fluoroarylation of aminoalkenes.
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DOI：
10.1021/jacs.5b07795
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发表时间：
2015-09-30
影响因子：
15
通讯作者：
Toste FD
中科院分区：
文献类型：
--
作者：
He Y;Yang Z;Thornbury RT;Toste FD
本文报道了钯催化未活化的氨基烯烃的1，1-氟芳基化反应。该反应使用芳基硼酸作为芳烃源和Selectfluor作为氟源，以良好的产率和优异的对映选择性生成苄基氟。这种转化可能通过氧化Heck机理进行，得到1，1-二官能化烯烃产物。
The development of an enantioselective palladium-catalyzed 1,1-fluoroarylation of unactivated aminoalkenes is described. The reaction uses arylboronic acids as the arene source and Selectfluor as the fluorine source to generate benzylic fluorides in good yields with excellent enantioselectivities. This transformation, likely proceeding through an oxidative Heck mechanism, affords 1,1-difunctionalized alkene products.