V-MAF, A VIRAL ONCOGENE THAT ENCODES A LEUCINE ZIPPER MOTIF - (AVIAN RETROVIRUS TRANSFORMATION DNA-BINDING PROTEIN)
V-MAF, A VIRAL ONCOGENE THAT ENCODES A LEUCINE ZIPPER MOTIF - (AVIAN RETROVIRUS TRANSFORMATION DNA-BINDING PROTEIN)
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DOI：
10.1073/pnas.86.20.7711
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发表时间：
1989-10-01
影响因子：
11.1
通讯作者：
KAWAI, S
中科院分区：
文献类型：
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作者：
NISHIZAWA, M;KATAOKA, K;KAWAI, S
我们已经分子克隆了禽肌肉腱膜纤维肉瘤病毒AS 42的前病毒。对AS 42的一个生物活性克隆的核苷酸序列分析表明，该病毒编码一个病毒癌基因maf。推导的氨基酸序列的v-maf基因产物含有一个“亮氨酸拉链”基序类似于发现在许多DNA结合蛋白，包括基因产物的fos，jun和myc癌基因。然而，与这些癌基因不同的是，细胞maf基因不会被培养细胞的生长刺激转录激活。
We have molecularly cloned the provirus of the avian musculoaponeurotic fibrosarcoma virus AS42. Nucleotide sequence analysis of a biologically active clone of AS42 showed that this virus encodes a viral oncogene, maf. The deduced amino acid sequence of the v-maf gene product contains a "leucine zipper" motif similar to that found in a number of DNA bindings proteins, including the gene products of the fos, jun, and myc oncogenes. However, unlike these oncogenes, the cellular maf gene was not transcriptionally activated by growth stimulation of cultured cells.