Effect of exercise training on left ventricular performance in older women free of cardiopulmonary disease.
Effect of exercise training on left ventricular performance in older women free of cardiopulmonary disease.
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DOI：
10.1016/0002-9149(93)90718-r
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
R. Spina;T. Ogawa;Tom R. Miller;Wendy M. Kohrt;A. Ehsani
中科院分区：
文献类型：
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作者：
R. Spina;T. Ogawa;Tom R. Miller;Wendy M. Kohrt;A. Ehsani
耐力运动训练增加有氧运动能力(最大耗氧率[V̇O2max])，并缓解老年男性运动期间与年龄相关的左心室(LV)功能下降。为了确定老年女性是否也有类似的适应，10名受试者(年龄63±4岁，平均年龄±SE)在9~12个月的耐力运动训练前后进行了研究。以最大心率的81±0.3%进行每周3.85±0.06天的运动。静息和仰卧位运动时的左心功能通过核素心动图进行评估。V̇O2max增加21%(从1.4±0.1L/m in增加到1.7±0.1L/min；p<；0.001)。运动前最大心率161±5次/min，运动后最大收缩压164±3次/min，P=NS，运动前208±7 mm Hg，运动后214±8 mm Hg，P=NS。安静时(训练前为70.4±2%，训练后为70±1%)和高峰运动时(训练前为78.6±2%，训练后为79.3±2%)对训练无明显影响。运动前后射血分数变化相似(分别为8.8±1vs9.1±1%)。每搏输出量和运动高峰时的心输出量也不会因训练而改变。运动训练未引起左心室增大，表现为左心室舒张末容量无增加(静息：117±6vs108±9ml，p=NS；运动前124±7ml vs123±9ml；p=NS)。收缩末期容量(安静前：33±2ml，P=NS；运动前：28±3ml，P=NS；运动后：25±2ml，P=NS)，收缩压-收缩末期容量关系无变化。结果表明，耐力训练主要通过外周适应提高老年女性的V-̇-O2max，而不会导致左心室增大或左心室收缩功能增强。
Endurance exercise training increases aerobic exercise capacity (maximal oxygen consumption rate [V̇O2max]) and attenuates the age-related decline in left ventricular (LV) function during exercise in older men. To determine whether similar adaptations occur in older women, 10 subjects (aged 63 ± 4 years mean ± SE) were studied before and after 9 to 12 months of endurance exercise training. They exercised 3.85 ± 0.06 days/week at 81 ± 0.3% of maximal heart rate. LV function at rest and during supine exercise was assessed by radionuclide ventriculography. V̇O2max was increased by 21% (from 1.40 ± 0.1 to 1.7 ± 0.1 liter/min; p < 0.001) in response to training. Maximal heart rate and systolic blood pressure during treadmill exercise were unchanged (161 ± 5 beats/min before vs 164 ± 3 beats/min after; p = NS, and 208 ± 7 mm Hg before vs 214 ± 8 mm Hg after; p = NS, respectively) after training. LV ejection fraction at rest (70.4 ± 2% before vs 70 ± 1% after) and during peak exercise (78.6 ± 2% before vs 79.3 ± 2% after) did not change in response to training. Furthermore, the increases in ejection fraction from rest to exercise were similar before and after training (change: 8.8 ± 1 vs 9.1 ± 1%). Stroke volume and cardiac output at peak exercise also did not change in response to training. Exercise training did not induce LV enlargement as evidenced by absence of an increase in LV end-diastolic volume (rest: 117 ± 6 vs 108 ± 9 ml, p = NS; exercise 124 ± 7 ml before vs 123 ± 9 ml after; p = NS). End-systolic volume (rest: 33 ± 2 ml before vs 33 ± 2 ml after, p = NS; exercise: 28 ± 3 ml before vs 25 ± 2 ml after, p = NS), and systolic blood pressure-end systolic volume relation did not change. The results indicate that endurance exercise training improves V̇O2max in older women primarily by means of peripheral adaptations without inducing LV enlargement or enhancement of LV systolic function.