Large scale commercial fabrication of high quality graphene-based assays for biomolecule detection
Large scale commercial fabrication of high quality graphene-based assays for biomolecule detection
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DOI：
10.1016/j.snb.2016.09.137
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发表时间：
2017-02-01
影响因子：
8.4
通讯作者：
Goldsmith, Brett R.
中科院分区：
文献类型：
--
作者：
Lerner, Mitchell B.;Pan, Deng;Goldsmith, Brett R.
采用化学气相沉积技术制备了大量迁移率约为5000 cm(2)/V*s的高质量石墨烯晶体管，并将其封装在具有开腔设计的陶瓷载体中。陶瓷载体与标准电子组件兼容，无需大型昂贵的探测系统，即可在工作台上读出石墨烯特性。经过化学功能化后，这些传感器表现出在pM范围内的灵敏度和对许多类生物分子的选择性，作为三端液体门控场效应晶体管。使用该技术捕获的蛋白质动力学的高精度测量，商业上称为AGILE R100，可与最先进的生物分子表征工具相媲美，并且可以超越其能力。(C) 2016年Elsevier B.V.出版
Large numbers of high quality graphene transistors with mobility approximately 5000 cm(2)/V*s were fabricated by chemical vapor deposition and packaged into ceramic carriers with an open cavity design. The ceramic carrier is compatible with standard electronics assembly, enabling the readout of graphene properties on the benchtop without large, expensive probing systems. After chemical functionalization, these sensors demonstrate sensitivity in the pM range and selectivity to many classes of biomolecules as a three terminal liquid-gated field effect transistor. High precision measurements of protein kinetics captured using this technology, commercially known as AGILE R100, are comparable and can exceed the capabilities of state-of-the-art biomolecule characterization tools. (C) 2016 Published by Elsevier B.V.