Neural Activity Patterns Underlying Spatial Coding in the Hippocampus.
Neural Activity Patterns Underlying Spatial Coding in the Hippocampus.
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DOI：
10.1007/7854_2016_462
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发表时间：
2018
影响因子：
--
通讯作者：
Frank LM
中科院分区：
文献类型：
--
作者：
Sosa M;Gillespie AK;Frank LM
众所周知，海马体是记忆处理的中心位置--这对存储和后来检索日常生活中的经历事件至关重要，这样它们就可以用来塑造未来的行为。我们对海马体功能背后的生理学所知的很大一部分来自啮齿动物的空间导航研究，这些研究使我们在理解海马体如何在细胞水平上代表经验方面取得了很大进展。然而，要协调我们对海马体空间编码的知识与它在人类和其他动物的记忆依赖任务中所展示的作用，仍然是一个挑战。此外，我们对神经元网络如何协调它们在海马亚区内和跨海马亚区的活动以实现记忆的编码、巩固和检索的理解是不完整的。在这一章中，我们探索信息如何在细胞水平上被表达，并通过整个海马区网络各亚区的协调活动模式进行处理。
The hippocampus is well known as a central site for memory processing—critical for storing and later retrieving the experiences events of daily life so they can be used to shape future behavior. Much of what we know about the physiology underlying hippocampal function comes from spatial navigation studies in rodents, which have allowed great strides in understanding how the hippocampus represents experience at the cellular level. However, it remains a challenge to reconcile our knowledge of spatial encoding in the hippocampus with its demonstrated role in memory-dependent tasks in both humans and other animals. Moreover, our understanding of how networks of neurons coordinate their activity within and across hippocampal subregions to enable the encoding, consolidation, and retrieval of memories is incomplete. In this chapter, we explore how information may be represented at the cellular level and processed via coordinated patterns of activity throughout the subregions of the hippocampal network.