Bone morphogenetic proteins in development
Bone morphogenetic proteins in development
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DOI：
10.1016/s0959-437x(96)80064-5
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发表时间：
1996-08-01
影响因子：
4
通讯作者：
Hogan, BLM
中科院分区：
文献类型：
--
作者：
Hogan, BLM
骨形态发生蛋白（BMP）是一个与转化生长因子β超家族成员相关的细胞因子大家族。最近的证据，特别是来自小鼠基因靶向实验的证据表明，BMP是中胚层形成以及许多不同器官系统的发育和模式化所必需的。在了解BMP在非洲爪蟾原肠胚形成和神经胚形成中的作用以及鉴定调节BMP表达的基因和下游信号通路的组分方面也取得了重大进展。BMP活性的细胞外修饰剂可能构成相反的形态发生系统。
The bone morphogenetic proteins (BMPs) constitute a large family of cytokines related to members of the transforming growth factor-beta superfamily. Recent evidence, in particular from gene targeting experiments in the mouse, indicates that BMPs are required for mesoderm formation and for the development and patterning of many different organ systems. Significant progress has also been made in understanding the role of BMPs in gastrulation and neurulation in Xenopus and in identifying genes regulating BMP expression and components of the downstream signaling pathways. Extracellular modifiers of BMP activity may constitute an opposing morphogenetic system.