Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue
Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue
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DOI：
10.1016/s0021-9290(03)00257-4
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发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Keaveny, TM
中科院分区：
文献类型：
--
作者：
Bayraktar, HH;Morgan, EF;Keaveny, TM
确定骨小梁组织弹性和失效特性的能力具有生物学和临床重要性。迄今为止，由于实验困难，小梁组织屈服应变仍然未知，弹性模量研究报告了有争议的结果。我们假设小梁组织的弹性、拉伸和压缩屈服特性与皮质组织相似。结合表观机械测试和标本特异性高分辨率非线性有限元建模，对取自 11 名捐献者的尸体股骨颈标本的有效组织模量和屈服应变进行了校准。然后将小梁组织特性与从 34 名捐赠者的类似队列中获得的人类股骨骨干皮质骨样本的测量弹性模量和拉伸屈服应变进行比较。通过统计消除血管孔隙度的影响获得皮质组织特性。结果表明，小梁组织的平均弹性模量 (18.0 +/- 2.8 GPa) 比皮质组织 (19.9 +/- 1.8 GPa) 低 10% (p < 0.05)，小梁组织的 0.2% 偏移拉伸屈服应变低 15%（0.62 +/- 0.04% 与 0.73 +/- 0.05%， p < 0.001）。小梁组织的拉伸-压缩屈服强度不对称性平均为 0.62，与文献中报告的皮质骨值相似。我们得出的结论是，虽然小梁组织的弹性模量和屈服应变仅略低于皮质组织，但由于这些差异的累积效应，皮质骨的组织强度大约高 25%。 (C) 2003 Elsevier Ltd. 保留所有权利。
The ability to deter-mine trabecular bone tissue elastic and failure properties has biological and clinical importance. To date, trabecular tissue yield strains remain unknown due to experimental difficulties, and elastic moduli studies have reported controversial results. We hypothesized that the elastic and tensile and compressive yield properties of trabecular tissue are similar to those of cortical tissue. Effective tissue modulus and yield strains were calibrated for cadaveric human femoral neck specimens taken from 11 donors, using a combination of apparent-level mechanical testing and specimen-specific, high-resolution, nonlinear finite element modeling. The trabecular tissue properties were then compared to measured elastic modulus and tensile yield strain of human femoral diaphyseal cortical bone specimens obtained from a similar cohort of 34 donors. Cortical tissue properties were obtained by statistically eliminating the effects of vascular porosity. Results indicated that mean elastic modulus was 10% lower (p < 0.05) for the trabecular tissue (18.0 +/- 2.8 GPa) than for the cortical tissue (19.9 +/- 1.8 GPa), and the 0.2% offset tensile yield strain was 15% lower for the trabecular tissue (0.62 +/- 0.04% vs. 0.73 +/- 0.05%, p < 0.001). The tensile-compressive yield strength asymmetry for the trabecular tissue, 0.62 on average, was similar to values reported in the literature for cortical bone. We conclude that while the elastic modulus and yield strains for trabecular tissue are just slightly lower than those of cortical tissue, because of the cumulative effect of these differences, tissue strength is about 25% greater for cortical bone. (C) 2003 Elsevier Ltd. All rights reserved.