Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics
Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics
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DOI：
10.1016/j.bmcl.2017.08.027
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发表时间：
2017-09-15
影响因子：
2.7
通讯作者：
Gonzalez-Bello, Concepcion
中科院分区：
文献类型：
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作者：
Gonzalez-Bello, Concepcion
病原菌对可用抗生素的耐药性目前是一个全球性挑战，因为对多种类型抗生素具有耐药性的菌株数量每年急剧增加，并已在全球范围内蔓延。为了解决这个问题，现在正在开发与抗生素组合使用“抗生素佐剂”。这种方法使我们能够延长这些救命药物的使用寿命。本文综述了抗生素佐剂的主要类型、作用基础和有待解决的问题。特别强调的是那些已经在临床开发的化合物，即β-内酰胺酶抑制剂。(C)2017作者（S）爱思唯尔有限公司出版
Resistance to available antibiotics in pathogenic bacteria is currently a global challenge since the number of strains that are resistant to multiple types of antibiotics has increased dramatically each year and has spread worldwide. To unlock this problem, the use of an 'antibiotic adjuvant' in combination with an antibiotic is now being exploited. This approach enables us to prolong the lifespan of these life-saving drugs. This digests review provides an overview of the main types of antibiotic adjuvants, the basis of their operation and the remaining issues to be tackled in this field. Particular emphasis is placed on those compounds that are already in clinical development, namely beta-lactamase inhibitors. (C) 2017 The Author(s). Published by Elsevier Ltd.