Estrogen and progesterone regulate opiate receptor densities in multiple brain regions.
Estrogen and progesterone regulate opiate receptor densities in multiple brain regions.
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DOI：
10.1210/endo-126-2-804
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发表时间：
1990-02
期刊：
影响因子：
4.8
通讯作者：
N. Weiland;P. Wise
中科院分区：
文献类型：
--
作者：
N. Weiland;P. Wise
雌激素和孕激素对下丘脑的负反馈和正反馈作用可能部分由内源性阿片系统介导。雌激素和黄体酮抑制对阿片肽的生理反应。为了确定这种对阿片类药物的脱敏是否与受体下调有关，我们测量了下丘脑调节促性腺激素释放和/或性行为的纳洛酮结合位点的密度。使用放射自显影技术，我们测量了纳洛酮结合位点的密度在一天中的不同时间在完整的发情大鼠，去卵巢大鼠，或去卵巢大鼠治疗雌激素或雌激素加黄体酮。与完整的大鼠相比，卵巢切除术增加了所有下丘脑区域的纳洛酮结合位点。雌激素治疗降低，雌激素加孕酮治疗降低纳洛酮结合位点密度更大。这种类固醇诱导的阿片受体抑制似乎具有重要的生理影响，并为之前观察到的类固醇诱导的对外源性阿片的差异敏感性提供了基础。
The negative and positive feedback, actions of estrogen and progesterone on the hypothalamus may be mediated in part by the endogenous opiate system. Estrogen and progesterone suppress physiological responses to the administration of opiate peptides. To determine whether this desensitization to opiates involves receptor down-regulation, we measured the density of naloxone-binding sites in hypothalamic regions regulating gonadotropin release and/or sexual behavior. Using autoradiographic techniques, we measured the density of naloxone-binding sites at various times of the day in intact proestrous, ovariectomized, or ovariectomized rats treated with estrogen or estrogen plus progesterone. Ovariectomy increased naloxone-binding sites compared to intact proestrous rats in all hypothalamic regions examined. Treatment with estrogen decreased and treatment with estrogen plus progesterone decreased even more the densities of naloxone-binding sites. This steroid-induced suppression of opiate receptors appears to have important physiological repercussions and provides a basis for the steroid-induced differential sensitivity to exogenous opiates that has been observed previously.