Growth curves for cardio-metabolic risk factors in children and adolescents.
Growth curves for cardio-metabolic risk factors in children and adolescents.
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DOI：
10.1016/j.jpeds.2009.04.051
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发表时间：
2009-09-01
期刊：
影响因子：
--
通讯作者：
Huang, Terry T-K
中科院分区：
文献类型：
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作者：
Cook, Stephen;Auinger, Peggy;Huang, Terry T-K
目的：本研究开发的百分位曲线人体测量（腰围）和心血管（血脂）的危险因素为US children and adolescents.Study设计：一个有代表性的美国儿童和青少年从国家健康和营养检查调查1988年至1994年（NHANES III）和目前的国家系列（NHANES 1999-2006）的样本相结合。百分位数曲线构建，全国加权，并使用λ，Mu和Sigma方法平滑。百分位数曲线包括年龄和性别特异性百分位数值，这些百分位数值对应于这些人体测量和心血管组件中的每一个的成人异常截止值并过渡到成人异常截止值。为了增加样本量，还结合2个NHANES数据库，沿着来自博加卢萨心脏研究、马斯卡廷研究、费尔斯纵向研究和普林斯顿脂质研究临床研究的横截面数据，创建了第二系列百分位数曲线。这些分析得出了一系列腰围、总胆固醇、LDL胆固醇、甘油三酯和高密度脂蛋白胆固醇。成年男性腰围异常的临界值（102 cm）相当于18岁青少年的第94百分位数，成年女性腰围异常的临界值（88 cm）相当于18岁青少年的第84百分位数。甘油三酯被发现有一个双峰模式的女性，在11岁和20岁的第二个初始峰值;男性的曲线随着年龄的增长稳步上升。女性的HDL曲线相对平坦，但男性曲线从9岁开始下降。雄性和雌性动物的总胆固醇和LDL胆固醇曲线相似。当从额外的儿童研究的数据被添加到国家的数据，有他们的模式或变化率从一年到一年的year.CONCLUSIONS：这些曲线代表腰部和脂质脂肪脂肪酸为美国儿童和青少年，与识别的值过渡到成人异常的差异不大。它们可以有条件地用于流行病学和可能的临床应用，尽管它们需要根据纵向数据进行验证。
OBJECTIVE: This study developed percentile curves for anthropometric (waist circumference) and cardiovascular (lipid profile) risk factors for US children and adolescents.STUDY DESIGN: A representative sample of US children and adolescents from the National Health and Nutrition Examination Survey from 1988 to 1994 (NHANES III) and the current national series (NHANES 1999-2006) were combined. Percentile curves were constructed, nationally weighted, and smoothed using the Lambda, Mu, and Sigma method. The percentile curves included age- and sex-specific percentile values that correspond with and transition into the adult abnormal cut-off values for each of these anthropometric and cardiovascular components. To increase the sample size, a second series of percentile curves was also created from the combination of the 2 NHANES databases, along with cross-sectional data from the Bogalusa Heart Study, the Muscatine Study, the Fels Longitudinal Study and the Princeton Lipid Research Clinics Study.RESULTS: These analyses resulted in a series of growth curves for waist circumference, total cholesterol, LDL cholesterol, triglycerides, and HDL cholesterol from a combination of pediatric data sets. The cut-off for abnormal waist circumference in adult males (102 cm) was equivalent to the 94(th) percentile line in 18-year-olds, and the cut-off in adult females (88 cm) was equivalent to the 84(th) percentile line in 18-year-olds. Triglycerides were found to have a bimodal pattern among females, with an initial peak at age 11 and a second at age 20; the curve for males increased steadily with age. The HDL curve for females was relatively flat, but the male curve declined starting at age 9 years. Similar curves for total and LDL cholesterol were constructed for both males and females. When data from the additional child studies were added to the national data, there was little difference in their patterns or rates of change from year to year.CONCLUSIONS: These curves represent waist and lipid percentiles for US children and adolescents, with identification of values that transition to adult abnormalities. They could be used conditionally for both epidemiological and possibly clinical applications, although they need to be validated against longitudinal data.