Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey
Prevalence of the metabolic syndrome in patients with gout: The Third National Health and Nutrition Examination Survey
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DOI：
10.1002/art.22466
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发表时间：
2007-02-15
期刊：
影响因子：
--
通讯作者：
Curhan, Gary
中科院分区：
文献类型：
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作者：
Choi, Hyon K.;Ford, Earl S.;Curhan, Gary
Objective.确定代谢综合征在痛风患者中的患病率，并在具有全国代表性的美国成年人样本中检查2种情况之间的关联。使用第三次全国健康与营养检查调查（1988-1994）中8，807名年龄≥ 20岁的参与者的数据，我们确定了痛风患者中代谢综合征的患病率，并量化了两种疾病之间的关联程度。我们使用修订的和原始的国家胆固醇教育计划成人治疗小组III（NCEP/ATP III）标准来定义代谢综合征。根据修订的NCEP/ATP III标准，痛风患者的代谢综合征患病率（95%置信区间[95%CI]）为62.8%（51.9-73.6），非痛风患者为25.4%（23.5-27.3）。使用2002年人口普查数据，类似于350万有痛风史的美国成年人患有代谢综合征。痛风患者代谢综合征的未校正和年龄、性别校正比值比（95%CI）分别为4.96（3.17-7.75）和3.05（2.01-4.61）。使用原始NCEP/ATP标准，相应的患病率略低，而相应的比值比略高。根据痛风的主要相关因素（即，体重指数、高血压和糖尿病）在痛风患者中仍显著高于非痛风患者（P均<0. 05）。这些发现表明，痛风患者中代谢综合征的患病率非常高。考虑到与代谢综合征相关的严重并发症，在痛风患者的长期治疗和整体健康中应认识到并考虑这种常见的合并症。
Objective. To determine the prevalence of metabolic syndrome among patients with gout and to examine the association between the 2 conditions in a nationally representative sample of US adults.Methods. Using data from 8,807 participants age >= 20 years in the Third National Health and Nutrition Examination Survey (1988-1994), we determined the prevalence of metabolic syndrome among individuals with gout and quantified the magnitude of association between the 2 conditions. We used both the revised and original National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) criteria to define metabolic syndrome.Results. The prevalence (95% confidence interval [95% CI]) of metabolic syndrome according to revised NCEP/ATP III criteria was 62.8% (51.9-73.6) among individuals with gout and 25.4% (23.5-27.3) among individuals without gout. Using 2002 census data, similar to 3.5 million US adults with a history of gout have metabolic syndrome. The unadjusted and age- and sex-adjusted odds ratios (95% CI) of metabolic syndrome for individuals with gout were 4.96 (3.17-7.75) and 3.05 (2.01-4.61), respectively. With the original NCEP/ATP criteria, the corresponding prevalences were slightly lower, whereas the corresponding odds ratios were slightly higher. The stratified prevalences of metabolic syndrome by major associated factors of gout (i.e., body mass index, hypertension, and diabetes) remained substantially and significantly higher among those with gout than those without gout (all P values < 0.05).Conclusion. These findings indicate that the prevalence of metabolic syndrome is remarkably high among individuals with gout. Given the serious complications associated with metabolic syndrome, this frequent comorbidity should be recognized and taken into account in long-term treatment and overall health of individuals with gout.