Risk factors for oral human papillomavirus in adults infected and not infected with human immunodeficiency virus
Risk factors for oral human papillomavirus in adults infected and not infected with human immunodeficiency virus
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DOI：
10.1097/00007435-199701000-00006
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发表时间：
1997-01-01
影响因子：
3.1
通讯作者：
Ghadirian, P
中科院分区：
文献类型：
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作者：
Coutlee, F;Trottier, AM;Ghadirian, P
目的：探讨口腔人乳头瘤病毒感染的影响因素。目的：探讨口腔人乳头瘤病毒感染的流行情况和危险因素。研究设计：从性传播疾病-人类免疫缺陷病毒门诊和胃肠内窥镜门诊连续招募178例人类免疫缺陷病毒阳性者(男158例，女20例)和人类免疫缺陷病毒阴性者109例(男73例，女36例)。与口腔人乳头瘤病毒感染相关的单变量分析是人类免疫缺陷病毒感染(优势比，6.9；95%可信区间2.0-23.2)、同性恋(优势比3.7；95%可信区间1.5-9.4)、无保护口交(优势比5.5；95%可信区间1.6-18.4)、梅毒(优势比2.5；95%可信区间1.1-6.3)、淋病(优势比4.2；95%可信区间1.9-9.1)、沙眼衣原体(优势比4.4；多因素逐步Logistic回归分析显示，生殖器疱疹(优势比为2.9；95%可信区间为1.3~6.5)、人类免疫缺陷病毒感染和沙眼衣原体感染是人乳头状瘤病毒感染的独立预测因素。结论：性行为在人乳头状瘤病毒口腔传播中起重要作用。
Background and Objectives: To investigate in a cross-sectional study the determinants of oral human papillomavirus infection in 287 individuals who are sexually active,Goal: To assess prevalence as well as risk factors for oral human papillomavirus infection,Study Design: One hundred seventy-eight human immunodeficiency virus-seropositive (158 men and 20 women) and 109 human immunodeficiency virus-negative (73 men and 36 women) individuals were recruited consecutively from sexually transmitted disease-human immunodeficiency virus clinics and gastrointestinal endoscopy clinics, Oral brushings were tested with the L1 consensus polymerase chain reaction assay for human papillomavirus detection,Results: Human papillomavirus DNA was detected in 32 (11.2%) of 287 individuals, Associated with oral human papillomavirus infection on univariate analyses were human immunodeficiency virus infection (odds ratio, 6.9; 95% confidence interval, 2.0-23.2), homosexuality (odds ratio, 3.7; 95% confidence interval, 1.5-9.4), unprotected oral sex (odds ratio, 5.5; 95% confidence interval, 1.6-18.4), syphilis (odds ratio, 2.5; 95% confidence interval, 1.1-6.3), gonorrhea (odds ratio, 4.2; 95% confidence interval, 1.9-9.1), Chlamydia trachomatis (odds ratio, 4.4; 95% confidence interval, 1.8-10.6), and genital herpes (odds ratio, 2.9; 95% confidence interval, 1.3-6.5), Human immunodeficiency virus infection and C. trachomatis were independently predictive of human papillomavirus infection in multivariate stepwise logistic regression.Conclusions: This study suggests that sexual activity plays an important role in the transmission of human papillomavirus in the oral cavity.