The Complex Exocrine-Endocrine Relationship and Secondary Diabetes in Exocrine Pancreatic Disorders
The Complex Exocrine-Endocrine Relationship and Secondary Diabetes in Exocrine Pancreatic Disorders
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DOI：
10.1097/mcg.0b013e31822a2ae5
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发表时间：
2011-11-01
影响因子：
2.9
通讯作者：
Pitchumoni, Capecomorin S.
中科院分区：
文献类型：
--
作者：
Chen, Nancy;Unnikrishnan, Ranjit, I;Pitchumoni, Capecomorin S.
胰腺是一个具有外分泌和内分泌功能的双重器官。胰腺的内分泌和外分泌部分的相互关系是复杂的，但最近的临床和实验研究扩大了我们的知识。许多主要是外分泌胰腺的疾病，通常仅在胃肠病学家的临床领域与糖尿病（DM）有关。虽然糖尿病成为疾病常与2型糖尿病归为一类，但其发病机制、临床表现和处理不同。我们回顾了外分泌-内分泌胰腺、胰腺的许多激素及其对外分泌功能的可能影响的相关数据，以及糖尿病在慢性胰腺炎、囊性纤维化、胰腺癌和胰腺手术后临床状态中的流行病学、发病机制和管理数据。
The pancreas is a dual organ with exocrine and endocrine functions. The interrelationship of the endocrine-exocrine parts of the pancreas is a complex one, but recent clinical and experimental studies have expanded our knowledge. Many disorders primarily of the exocrine pancreas, often solely in the clinical realm of gastroenterologists are associated with diabetes mellitus (DM). Although, the DM becoming disorders are often grouped with type 2 diabetes, the pathogenesis, clinical manifestations and management differ. We review here data on the association of exocrine-endocrine pancreas, the many hormones of the pancreas and their possible effects on the exocrine functions followed by data on the epidemiology, pathogenesis, and management of DM in chronic pancreatitis, cystic fibrosis, pancreatic cancer, and clinical states after pancreatic surgery.