ALS disease onset may occur later in patients with pre-morbid diabetes mellitus
ALS disease onset may occur later in patients with pre-morbid diabetes mellitus
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DOI：
10.1111/j.1468-1331.2009.02923.x
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发表时间：
2010-05-01
影响因子：
5.1
通讯作者：
Schulz, P. E.
中科院分区：
文献类型：
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作者：
Jawaid, A.;Salamone, A. R.;Schulz, P. E.
研究背景与2型糖尿病（DM）相关的代谢紊乱包括高脂血症和肥胖，与肌萎缩侧索硬化症（ALS）的良好预后相关。在这里，我们测试的假设，DM将有一个积极的影响，对运动和认知的结果ALS.Methods：我们比较了数据从ALS患者发病前DM（ALS-DM; n = 175）与无DM（ALS; n = 2196）方面的发病年龄，运动进展率，生存率，和神经心理测试performance.Results：发病年龄晚于女性，高加索人和延髓发作ALS患者。但在调整性别、种族和发病部位后，我们还发现DM与ALS的发病晚4年相关（ALS = 56.3，ALS-DM = 60.3，P < 0.05）。这些发现支持了其他研究表明ALS的病理生理学和代谢紊乱之间的关系。需要进一步的研究来确定操纵代谢参数是否会改善ALS的结果。
BackgroundSeveral metabolic derangements associated with diabetes mellitus type 2 (DM) have been associated with a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would have a positive effect on the motor and cognitive findings of ALS.Methods:We compared data from ALS patients with pre-morbid DM (ALS-DM; n = 175) versus without DM (ALS; n = 2196) with regard to the age of onset, rate of motor progression, survival, and neuropsychological test performance.Results:The age of onset was later for women, Caucasians and patients with bulbar-onset ALS. However, we also found that after adjusting for gender, ethnicity and site of onset, DM was associated with a 4-year later onset of ALS (ALS = 56.3, ALS-DM = 60.3, P < 0.05).Conclusion:Diabetes mellitus type 2 may delay the onset of motor symptoms in ALS. These findings support other studies suggesting a relationship between the pathophysiology of ALS and metabolic derangements. Further investigations are needed to ascertain whether manipulating metabolic parameters would improve outcomes in ALS.