Chlorella (Chlorella pyrenoidosa) supplementation decreases dioxin and increases immunoglobulin A concentrations in breast milk
Chlorella (Chlorella pyrenoidosa) supplementation decreases dioxin and increases immunoglobulin A concentrations in breast milk
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DOI：
10.1089/jmf.2006.023
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发表时间：
2007-03-01
影响因子：
2.4
通讯作者：
Nakano, Masuo
中科院分区：
文献类型：
--
作者：
Nakano, Shiro;Takekoshi, Hideo;Nakano, Masuo
除了满足营养需求外，母乳还在哺乳婴儿的生物防御中发挥着重要作用。在日本，母乳中检测到高浓度的二恶英，这引发了人们对含有二恶英的母乳给哺乳婴儿造成疾病的担忧。我们分析了日本35名孕妇的母乳和母体血液样本中的二恶英水平。我们还测量了母乳中的免疫球蛋白(Ig)A浓度，并研究了与二恶英浓度的相关性。此外，在35名妇女中，有18人在怀孕期间服用了蛋白核小球藻(小球藻)补充剂，并调查了补充剂对母乳中二恶英和免疫球蛋白A浓度的影响。服用小球藻片剂的妇女母乳中的毒性当量显著低于对照组(P=0.003)。这些结果表明，母亲补充小球藻可能会减少二恶英通过母乳转移到孩子身上。在对照组中，母乳中的二恶英和IgA浓度之间没有明显的相关性。通过食物接触正常水平的二恶英不太可能对母乳中的IgA产生显著影响。小球藻组母乳中IGA浓度显著高于对照组(P=0.03)。提高母乳中的IgA水平被认为有效地降低了哺乳婴儿的感染风险。目前的结果表明，补充小球藻不仅可以降低母乳中的二恶英水平，还可能通过提高母乳中的IgA水平而对哺乳婴儿产生有益的影响。
In addition to meeting nutritional requirements, breast milk plays important roles in biodefense for nursing infants. Dioxins have been detected at high concentrations in breast milk, raising concerns about disorders in nursing infants caused by breast milk containing dioxins in Japan. We analyzed dioxin levels in breast milk and maternal blood samples from 35 pregnant women in Japan. We also measured immunoglobulin (Ig) A concentrations in breast milk and investigated correlations with dioxin concentrations. In addition, 18 of the 35 women took Chlorella pyrenoidosa (Chlorella) supplements during pregnancy, and the effects on dioxin and IgA concentrations in breast milk were investigated. Toxic equivalents were significantly lower in the breast milk of women taking Chlorella tablets than in the Control group (P = .003). These results suggest that Chlorella supplementation by the mother may reduce transfer of dioxins to the child through breast milk. No significant correlation was identified between dioxin and IgA concentrations in breast milk in the Control group. It is unlikely that normal levels of dioxin exposure via food have a remarkable influence on IgA in breast milk. IgA concentrations in breast milk in the Chlorella group were significantly higher than in the Control group (P = .03). Increasing IgA levels in breast milk is considered to be effective for reducing the risk of infection in nursing infants. The present results suggest that Chlorella supplementation not only reduces dioxin levels in breast milk, but may also have beneficial effects on nursing infants by increasing IgA levels in breast milk.