The roles of several sensory neurons and the feedback from egg laying in regulating the germline response to a sex pheromone in C. elegans hermaphrodites.
The roles of several sensory neurons and the feedback from egg laying in regulating the germline response to a sex pheromone in C. elegans hermaphrodites.
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DOI：
10.17912/micropub.biology.000523
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发表时间：
2022
影响因子：
--
通讯作者：
Ruvinsky I
中科院分区：
文献类型：
--
作者：
Aprison EZ;Ruvinsky I
动物传播的小分子信息素可以改变同种动物的行为和生理。调控这些过程的神经元回路在很大程度上仍然未知。在秀丽隐杆线虫中，雄性富集的阿斯卡苷性信息素ascr#10除了行为效应外，还扩大了雌雄同体中生殖系前体细胞的数量。在此之前，我们确定了这种效果所需的几个感觉神经元。我们还发现，产卵的反馈通过血清素能信号传导，使信息素反应在繁殖的成虫中发挥作用。在这里，我们使用新的试剂，证实并扩展了我们之前的几个结论：a) ADL神经元对ascr#10反应至关重要，b)相粒神经元（PHA和PHB）不太可能参与ascr#10反应，c) mod-1受体是产蛋时血清素能反馈的主要通道，d)血清素仍然是目前唯一已知的反馈信号。我们的发现更好地定义了神经元回路，介导生殖细胞对主要雄性信息素的反应。
Animals broadcast small molecule pheromones that can alter behavior and physiology in conspecifics. Neuronal circuits that regulate these processes remain largely unknown. In C. elegans, male-enriched ascaroside sex pheromone ascr#10, in addition to behavioral effects, expands the population of germline precursor cells in hermaphrodites. Previously, we identified several sensory neurons required for this effect. We also found that feedback from egg laying acts via serotonergic signaling to license the pheromone response in reproducing adults. Here, using newly available reagents, we confirm and extend several of our previous conclusions: a) the ADL neurons are essential for the ascr#10 response, b) phasmid neurons (PHA and PHB) are unlikely to be involved in the ascr#10 response, c) the mod-1 receptor is the main conduit of the serotonergic feedback from egg laying, and d) serotonin remains the only currently known signal of this feedback. Our findings better define the neuronal circuits that mediate the germline response to the major male pheromone.