Melanocyte mutation in halo naevus and malignant melanoma?
Melanocyte mutation in halo naevus and malignant melanoma?
复制标题
晕痣和恶性黑色素瘤中的黑色素细胞突变？
DOI：
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发表时间：
1979
影响因子：
10.3
通讯作者：
P. Copeman
中科院分区：
文献类型：
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作者：
C. Bennett;P. Copeman
晕痣细胞与良性晕痣或恶性黑色素瘤患者的血清反应。晕痣细胞也与我们特异性吸收的异源抗人恶性黑色素瘤抗血清（RAMMA）反应。由于晕痣内所有痣细胞的细胞质都与恶性黑色素瘤患者的血清反应，这意味着痣中的整个黑色素细胞群都发生了突变，因为非病理性皮肤黑色素细胞不反应。
Halo naevus cells on frozen sections react with sera from patients with benign halo naevus or with malignant melanoma. Halo naevus cells also react with our specifically absorbed heterologous antihuman malignant melanoma antiserum (RAMMA). Since the cytoplasm of all the naevus cells within the halo naevus react with sera from patients with malignant melanoma, this implies that the entire population of melanocytic cells in the mole has undergone mutation, because non‐pathological skin melanocytes do not react.